|2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐|CsnPharm

CAS No.: 372196-77-5

PIK-75 HCl Catalog No. CSN18247

Synonyms: PIK-75 (hydrochloride);PIK-75 HCl

PIK-75 is a selective p110α inhibitor with IC50 of 5.8 nM with 200-fold more potently than p110β, and also potently inhibits DNA-PK with IC50 of 2 nM.

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400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述PIK-75 is a p110α inhibitor with IC50 of 5.8 nM(200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
human MV4-11 cells	-	Cytotoxic assay	72 h	Cytotoxicity against human MV4-11 cells after 72 hrs by CellTiter-Glo assay, IC50=0.003 μM	26349627
human NZB5 cells	-	Proliferation assay	-	Antiproliferative activity against human NZB5 cells, IC50=0.069 μM	17869522
human NZOV9 cells	-	Proliferation assay	-	Antiproliferative activity against human NZOV9 cells, IC50=0.066 μM	17869522

参考文献

[1] Zheng Z, Amran SI, et al. Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition. Mol Pharmacol. 2011 Oct;80(4):657-64.
[2] Moir LM, Trian T, et al. Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function. J Pharmacol Exp Ther. 2011 May;337(2):557-66.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0461 mL
- 10.2303 mL
- 20.4606 mL
- 5 mM
- 0.4092 mL
- 2.0461 mL
- 4.0921 mL
- 10 mM
- 0.2046 mL
- 1.0230 mL
- 2.0461 mL

技术信息

CAS号

372196-77-5

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H15BrClN5O4S

运输

蓝冰

分子量

488.74

别名

PIK-75 (hydrochloride);PIK-75 HCl

溶解度

DMSO	25.0 mg/mL (51.2 mM)
Water	insoluble

动物实验配方

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