生物活性

• 描述Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders^[3]. In vitro preincubation of brain membranes of aged mice with piracetam (0.1-1.0 mM) enhanced membrane fluidity, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH). Piracetam had similar in vitro effects on brain membranes of aged rats and humans, but it did not alter brain membrane fluidity in young mice. Chronic treatment of young and aged rats with piracetam (300 mg/kg once daily) significantly increased membrane fluidity in some brain regions of the aged animals, but had no measurable effect on membrane fluidity in the young rats^[4]. Piracetam (300 mg/kg daily for 6 weeks) improves active avoidance learning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in the aged rats. Piracetam (300 mg/kg daily for 6 weeks) also improves NMDA receptor density in the hippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to a lesser extent in the hippocampus of rats^[5]. Piracetam was also effective in the treatment of cognitive disorders of cerebrovascular and traumatic origins; however, its overall effect on lowering depression and anxiety was higher than improving memory^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00286260	Painful Polyneuropathy	Phase 4	Completed	-	Denmark ... more >> Department of Neurology, Odense University Hospital Odense C, Denmark, DK-5000 Collapse <<
  NCT00291213	Tardive Dyskinesia	Phase 3	Completed	-	United States, Connecticut ... more >> Connecticut Mental Health Center New Haven, Connecticut, United States, 06519 Collapse <<
  NCT00291655	Epilepsy	Phase 3	Completed	-	Belgium ... more >> Brugge, Belgium Edegem, Belgium Gent, Belgium Haine St Paul, Belgium Jette, Belgium Kortrijk, Belgium Leuven, Belgium Oostende, Belgium Bulgaria Sofia, Bulgaria Varna, Bulgaria Finland Hus (helsinki), Finland Kuopio, Finland Tampere, Finland France Blaye, France Bordeaux, France Brest, France Carcassonne, France Cherbourg, France Lille, France Lyon Cedex, France Nancy, France Rennes, France Saint Brieuc, France Saint Quentin, France TOULOUSE Cedex 04, France Valenciennes, France Poland Czestochowa, Poland Krakow, Poland Olstyn, Poland Poznan, Poland Warszawa, Poland Switzerland Biel, Switzerland Lausanne, Switzerland St Gallen, Switzerland Zurich, Switzerland Collapse <<

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• 参考文献

• [1] Mingeot-Leclercq MP, et al. Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment. Biochim Biophys Acta. 2003 Jan 10;1609(1):28-38.

  [2] Muller WE, Koch S, et al. Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain. Biochem Pharmacol. 1997 Jan 24;53(2):135-40.

  [3] Mingeot-Leclercq MP, Lins L, Bensliman M, Thomas A, Van Bambeke F, Peuvot J, Schanck A, Brasseur R. Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment. Biochim Biophys Acta. 2003 Jan 10;1609(1):28-38

  [4] Müller WE, Koch S, Scheuer K, Rostock A, Bartsch R. Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain. Biochem Pharmacol. 1997 Jan 24;53(2):135-40

  [5] Scheuer K, Rostock A, Bartsch R, Müller WE. Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain. Pharmacopsychiatry. 1999 Mar;32 Suppl 1:10-6

  [6] Malykh AG, Sadaie MR. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. Drugs. 2010 Feb 12;70(3):287-312

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