|(2S,3S)-3-((1S,3S,4R)-3,4-二羟基-1-甲氧基-2-羰基戊基)-2-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4-(((2S,4S,5R,6R)-4,5-二羟基-4,6-二甲基四氢-2H-吡喃-2-基)氧基)-5-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-8,9-二羟基-7-甲基-3,4-二氢蒽-1(2H)-酮|CsnPharm

CAS No.: 18378-89-7

Plicamycin Catalog No. CSN20483

Synonyms: Mithramycin A;aureolic acid;mithramycin

Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action, and inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

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描述Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action, and inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
参考文献

[1] Wei C, Zhang W, et al. Mithramycin A Alleviates Cognitive Deficits and Reduces Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease. Neurochem Res. 2016 Aug;41(8):1924-38.
[2] Saha S, Mukherjee S, et al. Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin. Transl Res. 2015 May;165(5):558-77.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.9215 mL
- 4.6077 mL
- 9.2153 mL
- 5 mM
- 0.1843 mL
- 0.9215 mL
- 1.8431 mL
- 10 mM
- 0.0922 mL
- 0.4608 mL
- 0.9215 mL

技术信息

CAS号	18378-89-7	储存条件	粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C52H76O24	运输	蓝冰
分子量	1085.15	别名	Mithramycin A;aureolic acid;mithramycin;Mithracin;Mithracine;MTH;A 2371;Antibiotic LA 7017;NSC 24559;mithramycin. US brand name: Mithracin. Foreign brand name: Mithracine. Abbreviation: MTH. Code names: A2371

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