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CAS No.: 145-13-1
Synonyms: 3β-Hydroxy-5-pregnen-20-one;Arthenolone;NSC 1616
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol which can act either as a neuroactive steroid or as a prohormone for progestogens, mineralocorticoids, glucocorticoids, androgens, estrogens, and the neuroactive steroids.
生物活性
靶点 | mAChR M1 IC50:11.4μM | mAChR M3 IC50:6.0μM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01327495 | Healthy | Phase 2 Phase 3 | Completed | - | United States, Washington ... more >> University of Washington Seattle, Washington, United States, 98195 Collapse << |
NCT01327495 | - | - | Completed | - | - |
NCT01650194 | Metastatic Castration-Resistan... more >>t Prostate Cancer Collapse << | Phase 2 | Completed | - | United States, Texas ... more >> Site US2492 MD Anderson Cancer Ctr Houston, Texas, United States, 77030 Collapse << |
实验方案
技术信息
CAS号 | 145-13-1 | 储存条件 |
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分子式 | C21H32O2 | 运输 | 蓝冰 | |||||
分子量 | 316.48 | 别名 | 3β-Hydroxy-5-pregnen-20-one;Arthenolone;NSC 1616;NSC 18158;Prenolon;Regnosone;Skinostelon;Enelone;Natolone;Pregnetan;Pregneton;Pregnolon;孕烯醇酮 | |||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01327495 | Healthy | Phase 2 Phase 3 | Completed | - | United States, Washington ... more >> University of Washington Seattle, Washington, United States, 98195 Collapse << |
NCT01327495 | - | - | Completed | - | - |
NCT01650194 | Metastatic Castration-Resistan... more >>t Prostate Cancer Collapse << | Phase 2 | Completed | - | United States, Texas ... more >> Site US2492 MD Anderson Cancer Ctr Houston, Texas, United States, 77030 Collapse << |
NCT03443895 | Healthy Volunteers | Phase 1 | Completed | - | United States, New Jersey ... more >> Biotrial Inc Newark, New Jersey, United States, 07103 Collapse << |
NCT03325595 | Healthy Volunteers | Phase 1 | Completed | - | United States, New Jersey ... more >> Biotrial Inc Newark, New Jersey, United States, 07103 Collapse << |
NCT02512458 | Bone Metastatic Prostate Cance... more >>r Collapse << | Phase 2 | Recruiting | July 2019 | Greece ... more >> Athens Medical Center, Dept of Medical Oncology Recruiting Athens, Maroussi, Greece, 15125 Contact: Eleni Efstathiou, MD EEfstathiou@mdanderson.org Principal Investigator: Eleni Efstathiou, MD EUROMEDICA General Clinic of Thessaloniki Recruiting Thessaloníki, Thessaloniki, Greece, 54645 Contact: George Fountzilas, Prof.Emeritus 00302310683136 fountzil@auth.gr General Hospital of Athens "Alexandra", Unit of Medical Oncology, Dept of Clinical Therapeutics Recruiting Athens, Greece, 11528 Contact: Meletios Athansios Dimopoulos, MD,Prof mdimop@med.uoa.gr Principal Investigator: Meletios Athanasios Dimopoulos, MD, Prof Agii Anargiri Cancer Hospital, 3rd Dept of Medical Oncology Recruiting Athens, Greece, 14564 Contact: Anastasios Visvikis, MD hecogaga@otenet.gr Principal Investigator: Anastasios Visvikis, MD Ioannina University Hospital, Dept of Medical Oncology Recruiting Ioannina, Greece, 45110 Contact: George Pentheroudakis, MD gpenther@otenet.gr Principal Investigator: George Pentheroudakis, Ass.Prof Papageorgiou General Hospital, Dept of Medical Oncology Completed Thessaloniki, Greece, 56429 Collapse << |
NCT02423096 | - | - | Unknown | December 2016 | Taiwan ... more >> Liang-Jen Wang Recruiting Kaohsiung, Taiwan Collapse << |
NCT00656318 | - | - | Terminated(Funding withdrawn f... more >>rom study sponsor.) Collapse << | - | United States, Connecticut ... more >> Yale University School of Medicine New Haven, Connecticut, United States, 06511 Collapse << |
NCT00626340 | - | - | Completed | - | - |
NCT00678574 | Premenstrual Dysphoric Disorde... more >>r Premenstrual Syndrome Collapse << | Phase 4 | Completed | - | United States, Connecticut ... more >> Yale University New Haven, Connecticut, United States, 06511 Collapse << |
NCT02256020 | Wheel-chair Dependent Elders | Not Applicable | Unknown | February 2015 | Taiwan ... more >> Division of Core Laboratory; Chang Bing Show Chwan Memorial Hospital Recruiting Changhua County, Taiwan Contact: Kuender D. Yang, PhD 886-975617006 yangkd.yeh@hotmail.com Collapse << |
NCT00678574 | - | - | Completed | - | - |
NCT02738580 | Infertility C... more >>ontrolled Ovarian Hyperstimulation Collapse << | Phase 4 | Completed | - | Spain ... more >> IVI Valencia Valencia, Spain, 46015 Collapse << |
NCT00044252 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00611975 | Healthy | Phase 4 | Completed | - | - |
NCT00626340 | Menopause Dep... more >>ression Collapse << | Phase 4 | Completed | - | United States, Connecticut ... more >> Yale University New Haven, Connecticut, United States, 06511 Collapse << |
NCT02582905 | Alcohol Use Disorder ... more >> Bipolar Disorder Collapse << | Phase 4 | Recruiting | December 2021 | United States, Florida ... more >> University of Miami Recruiting Miami, Florida, United States, 33136 Contact: Claudia Yaranga, BS 305-243-7276 ciy2@med.miami.edu Principal Investigator: Ihsan M. Salloum, MD, MPH United States, Texas UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Contact: Collette B. Bice, MS 214-645-6954 collette.bice@utsouthwestern.edu Principal Investigator: E. Sherwood Brown, M.D., Ph.D. Collapse << |
NCT01336413 | Brain Injuries, Traumatic | Phase 2 | Completed | - | United States, North Carolina ... more >> Durham VA Medical Center, Durham, NC Durham, North Carolina, United States, 27705 Collapse << |
NCT01956279 | Fatigue Muscu... more >>loskeletal Pain Cognitive Decline Collapse << | Phase 2 | Active, not recruiting | March 31, 2019 | United States, North Carolina ... more >> Durham VA Medical Center, Durham, NC Durham, North Carolina, United States, 27705 Collapse << |
NCT03589144 | - | - | Not yet recruiting | December 2019 | - |
NCT01898013 | Lower Back Pain | Phase 2 | Completed | - | United States, North Carolina ... more >> Durham VA Medical Center Durham, North Carolina, United States, 27705 Collapse << |
NCT00608686 | Alcohol Intoxication | Phase 1 | Unknown | March 2009 | United States, California ... more >> University of California, San Francisco San Francisco, California, United States, 94143 Collapse << |
NCT01336413 | - | - | Completed | - | - |
NCT01898013 | - | - | Completed | - | - |
NCT00912886 | - | - | Completed | - | France ... more >> Assistance publique - Hôpitaux de Paris Hôpital Bicêtre Le Kremlin Bicêtre, France, 94275 Inserm Umr 788 Le Kremlin Bicêtre, France, 94276 AP-HP Hôpital Rothschild Paris, France, 75012 Assistance Publique - Hôpitaux de Paris Hôpital Broca Paris, France, 75013 Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpétrière Paris, France, 75013 Assistance Publique - Hôpitaux de Paris, Hôpital Paul Brousse Villejuif, France, 94800 Collapse << |
NCT02576912 | Healthy | Phase 1 | Recruiting | December 2017 | United States, Connecticut ... more >> Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine Recruiting West Haven, Connecticut, United States, 06516 Contact: Ashley Sanders, BA 203-932-5711 ext 4495 ashley.sanders@yale.edu Contact: Christina Luddy, BS 203-932-5711 ext 4549 christina.luddy@yale.edu Principal Investigator: Deepak C D'Souza, MD Collapse << |
NCT00894842 | Schizophrenia | Phase 2 Phase 3 | Completed | - | Singapore ... more >> Institute of Mental Health Singapore, Singapore, 539747 Collapse << |
NCT00223197 | Bipolar Disorder ... more >> Major Depressive Disorder Substance Abuse Collapse << | Phase 4 | Completed | - | United States, Texas ... more >> The University of Texas Southwestern Medical Center Dallas, Texas, United States, 75390 Collapse << |
NCT00993629 | Post-traumatic Stress Disorder... more >> Major Depressive Disorder Collapse << | Phase 2 | Withdrawn(PI turned down fundi... more >>ng.) Collapse << | - | United States, North Carolina ... more >> VA Medical Center, Durham Durham, North Carolina, United States, 27705 Collapse << |
NCT02811939 | Healthy | Phase 1 | Recruiting | February 2018 | United States, Connecticut ... more >> Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine Recruiting West Haven, Connecticut, United States, 06516 Contact: Ashley Sanders, BA 203-932-5711 ext 4495 ashley.sanders@yale.edu Contact: Christina Luddy, BS (203) 932-5711 ext 4549 christina.luddy@yale.edu Principal Investigator: Deepak Cyril D'Souza, MD Collapse << |
NCT02826577 | Perceived Social Isolation | Phase 2 | Recruiting | June 1, 2019 | United States, Illinois ... more >> University of Chicago Recruiting Chicago, Illinois, United States, 60637 Contact: Erika Kaske 773-834-5264 ekaske@yoda.bsd.uchicago.edu Contact: Stephanie Cacioppo, PhD 773-702-6983 scacioppo@yoda.bsd.uchicago.edu Principal Investigator: Stephanie Cacioppo, PhD Sub-Investigator: Jon E Grant, JD, MD, MPH Sub-Investigator: Royce Lee, MD Collapse << |
NCT00615511 | Schizophrenia ... more >> Schizoaffective Disorder Collapse << | Phase 2 | Completed | - | United States, New Jersey ... more >> University of Medicine & Dentistry of New Jersey- University Behavioral HealthCare Piscataway, New Jersey, United States, 08854 United States, New York Weill Medical College of Cornell University New York, New York, United States, 10065 Weill Medical College of Cornell University White Plains, New York, United States, 10605 Collapse << |
NCT00847600 | Schizophrenia ... more >> Schizophreniform Disorder Schizoaffective Disorders Collapse << | Phase 4 | Completed | - | Israel ... more >> Shaar Menashe MHC and Tirat Carmel MHC Hadera, Israel, 38814 Collapse << |
NCT03505905 | Major Depressive Disorder ... more >> Menopause Perimenopause Collapse << | Phase 1 Phase 2 | Recruiting | March 2023 | United States, Texas ... more >> UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Contact: Stephanie Reyes stephanie.reyes@utsouthwestern.edu Collapse << |
NCT00560937 | Schizophrenia | Not Applicable | Completed | - | United States, North Carolina ... more >> Durham VAMC Durham, North Carolina, United States, 27705 Collapse << |
NCT00560937 | - | - | Completed | - | - |
NCT01831986 | Schizophrenia ... more >> Schizoaffective Disorder Collapse << | Not Applicable | Unknown | December 2013 | - |
NCT00623506 | Traumatic Brain Injury | Not Applicable | Completed | - | United States, North Carolina ... more >> Durham VA Medical Center Durham, North Carolina, United States, 27705 Collapse << |
NCT00174889 | Schizophrenia | Phase 1 | Completed | - | Israel ... more >> Sha'ar Menashe Mental Health Hadera, Israel, 38814 Collapse << |
NCT00623506 | - | - | Completed | - | - |
NCT00728728 | Schizophrenia ... more >> Schizoaffective Disorder Collapse << | Phase 2 | Completed | - | United States, North Carolina ... more >> Durham VA Medical Center, Durham, NC Durham, North Carolina, United States, 27705 Collapse << |
NCT00728728 | - | - | Completed | - | - |
NCT02439814 | - | - | Completed | - | - |
NCT00560781 | Stress Disorders, Post-Traumat... more >>ic Collapse << | Not Applicable | Completed | - | United States, North Carolina ... more >> Durham VAMC Durham, North Carolina, United States, 27705 Collapse << |
NCT02439814 | Marijuana Dependence | Phase 2 | Completed | - | United States, South Carolina ... more >> Medical University of South Carolina Charleston, South Carolina, United States, 29403 Collapse << |
NCT01949753 | Obsessive-compulsive Disorder ... more >>(OCD) Collapse << | Phase 2 | Recruiting | December 2018 | Germany ... more >> University Hospital Hamburg-Eppendorf Recruiting Hamburg, Germany Principal Investigator: Michael Kellner, MD, PhD Collapse << |
NCT01409096 | - | - | Completed | - | - |
NCT01409096 | Bipolar Disorder ... more >> Major Depressive Disorder Collapse << | Phase 4 | Completed | - | United States, Texas ... more >> The University of Texas Southwestern Medical Center Dallas, Texas, United States, 75235 Collapse << |
NCT01881737 | Autistic Disorder | Phase 2 | Completed | - | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 Collapse << |
NCT01881737 | - | - | Completed | - | - |
NCT03157778 | Obesity | Not Applicable | Completed | - | France ... more >> Hôpital Haut-Lévêque Pessac, France, 33600 Collapse << |
NCT03645096 | Major Depressive Disorder | Phase 1 | Not yet recruiting | December 2, 2020 | United States, Texas ... more >> UT Southwestern Medical Center Not yet recruiting Dallas, Texas, United States, 75390 Contact: Alexandra Kulikova, MS Contact 2146456967 alexandra.kulikova@utsouthwestern.edu Principal Investigator: Sherwood Brown, MD, PhD Collapse << |
NCT00900900 | Substance Withdrawal Syndrome | Phase 2 | Completed | - | United States, North Carolina ... more >> Duke Center for Nicotine & Smoking Cessation Research Durham, North Carolina, United States, 27705 Duke Center for Nicotine & Smoking Cessation Research Raleigh, North Carolina, United States, 27609 Collapse << |
NCT02627508 | Autism Spectrum Disorder ... more >> Autism Collapse << | Phase 2 | Recruiting | December 2019 | United States, California ... more >> Stanford University School of Medicine Recruiting Stanford, California, United States, 94305 Contact: Robin Libove 650-736-1235 rlibove@stanford.edu Principal Investigator: Antonio Y. Hardan, MD Sub-Investigator: Lawrence K. Fung, MD, PhD Collapse << |
靶点 | Description | IC50 |
---|---|---|
mAChR M1 | IC50:11.4μM | |
mAChR M3 | IC50:6.0μM |
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