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CAS No.: 1811-28-5

Proflavine Hemisulfate/硫酸原黄素 Catalog No. CSN11781

Synonyms: Proflavin hemisulfate;3,6-Diaminoacridine hemisulfate;Proflavine hemisulphate

Proflavine hemisulfate is an acridine-derived fluorescent contrast and disinfectant agent potentially used for cellular imaging and antiseptic purposes.

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技术信息

生物活性

描述Proflavine hemisulfate is an Acridine derivative, which is a slow-acting disinfectant with bacteriostatic action against many Gram-positive bacteria but less effective against Gram-negative organisms^[2]. Moreover, the bacteriostatic agent, proflavine, preferentially blocked a subset of inward rectifier K+ (Kir) channels^[3]. Mutants resistant to 1. 0 mM PF (Proflavine) were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells^[4]. In comparing proflavine-light and placebo-light treatment, 0. 1% proflavine administration twice daily for 5 days had a significant effect in suppressing herpetic eye disease, but 0. 05% proflavine was less effective^[5]. Proflavine hemisulfate, an acridine-derived fluorescent dye, can be used as a rapid stain for cytologic examination of biological specimens^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02494310	Neoplasia of the Uterine Cervi... more >>x Cancer Prevention Cervical Intraepithelial Neoplasia Collapse <<	Not Applicable	Completed	-	-
NCT02420665	Cervical Cancer	Early Phase 1	Active, not recruiting	September 2025	United States, Texas ... more >> Lyndon B. Johnson General Hospital Houston, Texas, United States, 77026 University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT02335372	Cervical Cancer	Not Applicable	Active, not recruiting	June 2020	Brazil ... more >> Barretos Cancer Hospital Barretos, Brazil, 14784-400 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2539 mL
- 16.2694 mL
- 32.5388 mL
- 5 mM
- 0.6508 mL
- 3.2539 mL
- 6.5078 mL
- 10 mM
- 0.3254 mL
- 1.6269 mL
- 3.2539 mL

技术信息

CAS号

1811-28-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H13N3O4S

运输

蓝冰

分子量

307.33

别名

Proflavin hemisulfate;3,6-Diaminoacridine hemisulfate;Proflavine hemisulphate;EINECS 217-320-3;3,6-Acridinediamine;sulfate (2:1);3,6 Diamino Acridine;Acridine;3,6-Diamino;Hemisulfate;Proflavine;硫酸原黄素

溶解度

DMSO	Insoluble
Water	20.0 mg/mL (65.1 mM)
Ethanol	Insoluble

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02494310	Neoplasia of the Uterine Cervi... more >>x Cancer Prevention Cervical Intraepithelial Neoplasia Collapse <<	Not Applicable	Completed	-	-
NCT02420665	Cervical Cancer	Early Phase 1	Active, not recruiting	September 2025	United States, Texas ... more >> Lyndon B. Johnson General Hospital Houston, Texas, United States, 77026 University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT02335372	Cervical Cancer	Not Applicable	Active, not recruiting	June 2020	Brazil ... more >> Barretos Cancer Hospital Barretos, Brazil, 14784-400 Collapse <<
NCT02790853	Dysplasia Lip... more >> and Oral Cavity Carcinoma Oral Disorder Premalignant Lesion Collapse <<	Early Phase 1	Recruiting	May 31, 2026	United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Ann M. Gillenwater 713-792-8841 Principal Investigator: Ann M. Gillenwater Collapse <<
NCT02095847	Uterine Cancer	Phase 2	Withdrawn	-	-
NCT02207959	Gastric Cancer	Phase 1	Terminated(PI left institution... more >>) Collapse <<	-	United States, New York ... more >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Collapse <<
NCT01269190	Oral Cavity Neoplasm	Early Phase 1	Recruiting	December 31, 2018	United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Ann M. Gillenwater 713-792-8841 Principal Investigator: Ann M. Gillenwater Collapse <<
NCT02206048	Cervix Carcinoma	Not Applicable	Active, not recruiting	October 2019	United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<
NCT02714439	Malignant Neoplasms of Female ... more >>Genital Organs Collapse <<	Early Phase 1	Active, not recruiting	July 2020	United States, Texas ... more >> University of Texas Medical Branch Cancer Stop McAllen Clinic McAllen, Texas, United States, 78501 Collapse <<
NCT01456143	-	-	Terminated(PI left, study to b... more >>e re-open with new PI, no planned data analysis) Collapse <<	-	-
NCT01456143	Squamous Cell Carcinoma ... more >> Neoplasia Head and Neck Cancer Collapse <<	Not Applicable	Terminated(PI left, study to b... more >>e re-open with new PI, no planned data analysis) Collapse <<	-	United States, New York ... more >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10017 Collapse <<
NCT01384695	GERD Barrett'... more >>s Esophagus Collapse <<	Early Phase 1	Terminated(Low/no enrollment. ... more >>No subjects were enrolled over the past year.) Collapse <<	-	United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse <<
NCT01384240	Colon Polyps ... more >>Colonic Dysplasia Anal Dysplasia Collapse <<	Early Phase 1	Terminated(Study is closed as ... more >>the PI transferred to another institution.) Collapse <<	-	United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse <<
NCT01384864	Barrett's Esophagus ... more >> Intraepithelial Neoplasia Collapse <<	Early Phase 1	Completed	-	United States, New York ... more >> Mount Sinai School of Medicine New York, New York, United States, 10029 Collapse <<
NCT01384708	Squamous Cell Cancer	Early Phase 1	Completed	-	United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse <<
NCT02029937	Suspected or Known Squamous Ce... more >>ll Neoplasia Prior History of Squamous Cell Dysplasia and /or Neoplasia Collapse <<	Phase 2	Recruiting	December 2020	United States, Texas ... more >> Baylor College of Medicine Recruiting Houston, Texas, United States, 77030 Principal Investigator: Sharmila Anandasabapathy, MD China, Jilin First Hospital of Jilin University Recruiting Changchun, Jilin, China Contact: Fan Zhang fanzhangchina@163.com Principal Investigator: Hong Xu China Cancer Institute and Hospital, Chinese Academy of Medical Sciences (CICAMS) Recruiting Beijing, China Contact: Yu Xinying littlenewyxy@163.com Principal Investigator: Guiqi Wang Collapse <<
NCT01384227	Barrett's Esophagus	Early Phase 1	Completed	-	United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse <<
NCT02018367	Barrett's Esophagus	Phase 2	Recruiting	June 2019	United States, Texas ... more >> Baylor College of Medicine Recruiting Houston, Texas, United States, 77030 Contact: Madeleine Allman, MPH 713-798-7585 madeleine.allman@bcm.edu Collapse <<

Proflavine Hemisulfate/硫酸原黄素 Catalog No. CSN11781

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