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CAS No.: 53-60-1

Promazine HCl/盐酸丙嗪 Catalog No. CSN11783

Synonyms: Romtiazin hydrochloride;Sinophenin hydrochloride;Romtiazin HCl

Promazine HCl is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.

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生物活性

描述Promazine HCl is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia. Male Wistar rats received promazine and/or an antidepressant (amitriptyline, imipramine) at a dose of 10 mg/kg i.p. twice a day for two weeks. In the brain, significant increases in the levels of promazine and its metabolites were observed after 6 and 12 h. In vitro studies with liver microsomes showed that chronic co-administration of the antidepressants did not significantly influence the rate of promazine demethylation and sulfoxidation^[3]. In vitro studies with liver microsomes of rats treated chronically with promazine, SSRIs or their combination did not show any significant changes in the concentrations of cytochromes P-450 and b-5. However, treatment with fluoxetine, alone or in a combination with promazine, decreased the rates of promazine N-demethylation and sulfoxidation. A similar effect was observed in the case of promazine and fluvoxamine combination^[4]. Male Sprague-Dawley rats were given promazine or chlorpromazine (25 mg/kg/day, P.O., in water) for 5 weeks. Food intake was decreased in promazine- and chlorpromazine-treated rats, chlorpromazine rats being affected more than promazine rats. Acid phosphatase activity in lavaged lung homogenate and macrophages of promazine- and chlorpromazine-treated rats, taken as an index of toxicity to cells, did not differ significantly from control rats^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1164 mL
- 15.5821 mL
- 31.1643 mL
- 5 mM
- 0.6233 mL
- 3.1164 mL
- 6.2329 mL
- 10 mM
- 0.3116 mL
- 1.5582 mL
- 3.1164 mL

技术信息

CAS号

53-60-1

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H21ClN2S

运输

蓝冰

分子量

320.88

别名

Romtiazin hydrochloride;Sinophenin hydrochloride;Romtiazin HCl;Sinophenin HCl;Promazine Hcl;Starazin;Talofen;Promazine monohydrochloride; Hydrochloride; Protactyl; Sinophenin; Sparine;盐酸丙嗪;Ampazine hydrochloride;Berophen hydrochloride

溶解度

DMSO	240.0 mg/mL (747.9 mM)
Water	330.0 mg/mL (1028.4 mM)

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