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CAS No.: 66532-86-3

盐酸丙帕他莫 Catalog No. CSN24044

Synonyms: Propacetamol Hydrochloride;盐酸丙帕他莫

Propacetamol HCl is the hydrochloride form of Propacetamol, which is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol is an analgesic drug delivered by IV when oral application of NSAID is not appropriate or contradicted.

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技术信息

生物活性

描述Propacetamol, a water-soluble prodrug form of paracetamol, is hydrolyzed by esterase to generate paracetamol in the blood. Administration of propacetamol can provoke a reduction in BP in ED (emergency department) patients^[1]. Intravenous propacetamol may be a safe and effective choice for pediatric URTI (upper respiratory tract infection) patients presenting with fever who are not able to take oral medications or need faster fever control^[2]. In the control group, 1.6 g mannitose in 100 ml NS intravenously as the placebo control to propacetamol with 50 mg dolantin (1.0 ml) intramuscularly as the positive control to propacetamol were administered. There was no significant difference (P = 0.93) about the area under the curve of "Pain Relieve Score vs. Time". The "starting to effect" time (15 - 30 min), analgesic duration (6h) and the percentage of excellent or good analgesic effect (90%) in the two groups were the same. Propacetamol HCL injection 2 g intravenously could be an alternative to dolantin 50 mg intramuscularly for moderate to severe postoperative pain with its advantage of being non-addictive^[3].
参考文献

[1] Bae JI, Ahn S, Lee YS, Kim WY, Lee JH, Oh BJ, Lim KS. Clinically significant hemodynamic alterations after propacetamol injection in the emergency department: prevalence and risk factors. Intern Emerg Med. 2017 Apr;12(3):349-355
[2] Choi SJ, Moon S, Choi UY, Chun YH, Lee JH, Rhim JW, Lee J, Kim HM, Jeong DC. The antipyretic efficacy and safety of propacetamol compared with dexibuprofen in febrile children: a multicenter, randomized, double-blind, comparative, phase 3 clinical trial. BMC Pediatr. 2018 Jun 23;18(1):201
[3] Ma EL, Wang XR, Jiang ZM, Cui Y, Wang R, Liu J. [A randomized, double blind, and controlled clinical trial of the non-addictive propacetamol in postoperative analgesia]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Jun;25(3):329-32. Chinese

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3247 mL
- 16.6234 mL
- 33.2468 mL
- 5 mM
- 0.6649 mL
- 3.3247 mL
- 6.6494 mL
- 10 mM
- 0.3325 mL
- 1.6623 mL
- 3.3247 mL

技术信息

CAS号	66532-86-3	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H21ClN2O3	运输	蓝冰
分子量	300.78	别名	Propacetamol Hydrochloride;盐酸丙帕他莫

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