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CAS No.: 2447066-37-5
Synonyms: CUN-01077;PD-L1 degrader P22
PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 degrader, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner.
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技术信息
CAS号 | 2447066-37-5 | 储存条件 |
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分子式 | C59H58ClN7O11 | 运输 | 蓝冰 | |
分子量 | 1076.59 | 别名 | CUN-01077;PD-L1 degrader P22 |
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