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CAS No.: 102036-29-3

Protosappanin B/原苏木素B Catalog No. CSN14661

Synonyms: 原苏木素B

Protosappanin B, a natural product isolated and purified from the heart wood of Caesalpinia sappan L., significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43, and induces the degradation of p53 protein, via activation of a MDM2-dependent ubiquitination process.

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技术信息

生物活性

描述Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity. Protosappanin B (2 mg/mL) reduced the viability of human bladder cancer T24 cells and mouse bladder cancer BTT cells in a time-dependent manner and significantly inhibited the growth of the human colon cancer cell lines HCT-116 and SW-480. IC50 values of 21.32, 26.73, and 76.53 µg/mL were obtained for SW-480, HCT-116, and BTT cells, respectively, after 48 hours of treatment with protosappanin B. In addition, pretreatment of H22 cells with protosappanin B (final concentration = 6.25 mg/mL) resulted in complete inhibition of tumor formation in KM mice. Furthermore, protosappanin B (200 and 300 mg/kg) significantly increased the survival of BTT tumor-bearing T739 mice, at a rate comparable to that of 1 mg/kg mitomycin^[3]. PSB (Protosappanin B) effectively inhibited the viability and migration of SW620 cells and induced apoptosis, but had poor effect on HCT116 cells^[4]. PTB (Protosappanin B) significantly increased cell viability, inhibited cell apoptosis and up-regulated the expression of growth-associated protein 43 (a marker of neural outgrowth)^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2863 mL
- 16.4314 mL
- 32.8629 mL
- 5 mM
- 0.6573 mL
- 3.2863 mL
- 6.5726 mL
- 10 mM
- 0.3286 mL
- 1.6431 mL
- 3.2863 mL

技术信息

CAS号

102036-29-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H16O6

运输

蓝冰

分子量

304.29

别名

原苏木素B

溶解度

DMSO	61.0 mg/mL (200.5 mM)

动物实验配方

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