|7-(2-羟丙基)-1,3-二甲基-3,7-二氢-1H-嘌呤-2,6-二酮|CsnPharm

CAS No.: 603-00-9

Proxyphylline/羟丙茶碱 Catalog No. CSN21946

Synonyms: Monophylline;Spasmolysin;NSC-163343

Proxyphylline is a xanthine-derivatived antagonists of A1 and A2 adenosine receptors, which relaxe smooth muscles, particularly bronchial muscles.

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生物活性

描述Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator^[1]. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline^[2]. Proxyphylline exhibits bronchodilatory effect^[3]. Proxyphylline inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentrations ^[4]. In guinea pigs (modified Konzett-Rössler method) the reduction in response to metacholine caused by increasing doses of proxyphylline and salbutamol significantly exceeded that of either drug alone. The combination of oral proxyphylline and salbutamol is clinically useful in increasing drug response without increased adverse effects^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1974 mL
- 20.9870 mL
- 41.9739 mL
- 5 mM
- 0.8395 mL
- 4.1974 mL
- 8.3948 mL
- 10 mM
- 0.4197 mL
- 2.0987 mL
- 4.1974 mL

技术信息

CAS号

603-00-9

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H14N4O3

运输

蓝冰

分子量

238.24

别名

Monophylline;Spasmolysin;NSC-163343;羟丙茶碱;茶碱

溶解度

DMSO	47.0 mg/mL (197.3 mM)

动物实验配方

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