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CAS No.: 179474-81-8
Synonyms: R-93877;R-108512;R-093877
Prucalopride is a high-affinity 5-HT4 receptor agonist。
生物活性
靶点 | 5-HT Receptor 4B pKi:8.1 | 5-HT Receptor 4A pKi:8.6 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT03610217 | Scleroderma, Systemic ... more >> Sclerosis, Systemic Collapse << | Not Applicable | Not yet recruiting | October 2021 | Canada, Ontario ... more >> Saint Joseph's Health Care London Not yet recruiting London, Ontario, Canada, n6a 4v2 Contact: Janet E Pope, MD, MPH, FRCPSC 15196466332 Janet.Pope@sjhc.london.on.ca Contact: Andreu Fernandez-Codina 151964661023 doccodina@gmail.com Collapse << |
NCT02538367 | Functional Constipation | Phase 1 Phase 2 | Completed | - | Korea, Republic of ... more >> Seoul National University Hospital Seoul, Korea, Republic of Collapse << |
NCT01902537 | - | - | Completed | - | Korea, Republic of ... more >> Seoul, Korea, Republic of Collapse << |
实验方案
技术信息
CAS号 | 179474-81-8 | 储存条件 |
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分子式 | C18H26ClN3O3 | 运输 | 蓝冰 | |||||||
分子量 | 367.87 | 别名 | R-93877;R-108512;R-093877;Motegrity;Resolor;Resotran;普芦卡必利 | |||||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT03610217 | Scleroderma, Systemic ... more >> Sclerosis, Systemic Collapse << | Not Applicable | Not yet recruiting | October 2021 | Canada, Ontario ... more >> Saint Joseph's Health Care London Not yet recruiting London, Ontario, Canada, n6a 4v2 Contact: Janet E Pope, MD, MPH, FRCPSC 15196466332 Janet.Pope@sjhc.london.on.ca Contact: Andreu Fernandez-Codina 151964661023 doccodina@gmail.com Collapse << |
NCT02538367 | Functional Constipation | Phase 1 Phase 2 | Completed | - | Korea, Republic of ... more >> Seoul National University Hospital Seoul, Korea, Republic of Collapse << |
NCT01902537 | - | - | Completed | - | Korea, Republic of ... more >> Seoul, Korea, Republic of Collapse << |
NCT02425774 | Postoperative Ileus | Phase 4 | Recruiting | December 2017 | Belgium ... more >> University hospitals Leuven Recruiting Leuven, Vlaams-Brabant, Belgium, 3000 Contact: Nathalie Stakenborg, MSc +32 16 342883 nathalie.stakenborg@med.kuleuven.be Contact: Kim Van Beek, MSc +32 16 341326 kim.vanbeek@med.kuleuven.be Principal Investigator: Guy Boeckxstaens, M.D. Collapse << |
NCT01655095 | Quality of Bowel Preparation f... more >>or the Colon Capsule Colon Capsule Completion Rates Colon Capsule Polyp Detection Collapse << | Phase 3 | Completed | - | Canada, Ontario ... more >> Hotel Dieu Hospital Kingston, Ontario, Canada Collapse << |
NCT00793429 | Healthy | Phase 1 | Completed | - | - |
NCT01870674 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... more >> Inje Busan Paik hospital Busan, Korea, Republic of, 614-735 Collapse << |
NCT00485940 | Constipation | Phase 3 | Completed | - | - |
NCT00627692 | Constipation | Phase 2 | Completed | - | - |
NCT00577018 | Constipation | Phase 3 | Completed | - | - |
NCT01070615 | Chronic Constipation | Phase 3 | Completed | - | Belgium ... more >> University Hospital Antwerp Edegem, Belgium, 2650 Collapse << |
NCT01330381 | Functional Constipation | Phase 3 | Completed | - | Netherlands ... more >> Academisch Medisch Centrum Amsterdam, Netherlands, 1105 AZ Collapse << |
NCT01869751 | - | - | Withdrawn(failure to recruit p... more >>atients) Collapse << | June 2016 | Belgium ... more >> University Hospitals Leuven Leuven, Vlaams-Brabant, Belgium, 3000 Collapse << |
NCT01330381 | - | - | Completed | - | - |
NCT00987844 | Chronic Constipation | Phase 3 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
NCT01036893 | Healthy Volunteers | Phase 1 | Completed | - | Germany ... more >> FOCUS GmbH Neuss, Germany, D-41460 Collapse << |
NCT00575614 | Constipation | Phase 2 | Completed | - | - |
NCT01134185 | Hepatic Impairment | Phase 1 | Completed | - | Russian Federation ... more >> Moscow, Russian Federation Collapse << |
NCT00483886 | Constipation | Phase 3 | Completed | - | - |
NCT00617513 | Constipation | Phase 2 | Completed | - | - |
NCT01147926 | Male Subjects With Chronic Con... more >>stipation Collapse << | Phase 3 | Completed | - | - |
NCT00598338 | Constipation | Phase 3 | Completed | - | - |
NCT02228616 | Constipation | Phase 4 | Completed | - | China ... more >> Beijing, China Bin Zhou, China Chongqing, China Hangzhou, China Nanjing, China Shanghai, China Tianjin, China Wuhan, China Zhengzhou, China Collapse << |
NCT01251822 | Constipation | Phase 3 | Completed | - | Romania ... more >> Pierrel Research Timisoara, Romania, RO-300244 Collapse << |
NCT01147926 | - | - | Completed | - | - |
NCT00631813 | Constipation | Phase 2 | Completed | - | - |
NCT00596596 | Constipation | Phase 2 | Completed | - | - |
NCT01707667 | Chronic Constipation | Phase 4 | Completed | - | United States, Oklahoma ... more >> Oklahoma Foundation for Digestive Research Oklahoma City, Oklahoma, United States Belgium UNIVERSITY OF LEUVEN, UNVERSITY HOSPITAL, Gasthuisberg Leuven, Belgium, 3000 United Kingdom Barts Health NHS Trust Whitechapel, London, United Kingdom Collapse << |
NCT01424228 | Constipation | Phase 4 | Completed | - | - |
NCT01707667 | - | - | Completed | - | - |
NCT00488137 | Constipation | Phase 3 | Completed | - | - |
NCT00576511 | Chronic Constipation | Phase 2 | Completed | - | - |
NCT01424228 | - | - | Completed | - | - |
NCT00793247 | Chronic Intestinal Pseudo-Obst... more >>ruction Collapse << | Phase 2 | Completed | - | United Kingdom ... more >> Northwick Park Hospital London, United Kingdom Collapse << |
NCT02031081 | Gastroparesis ... more >> Diabetes Mellitus Collapse << | Phase 2 Phase 3 | Completed | - | Canada, Alberta ... more >> University of Calgary Calgary, Alberta, Canada, T2N 4Z6 Collapse << |
NCT03244553 | Ineffective Esophageal Motilit... more >>y Dysphagia Collapse << | Phase 2 | Enrolling by invitation | December 2018 | Canada, Alberta ... more >> University of Calgary Calgary, Alberta, Canada, T2N 1N4 Collapse << |
NCT01807000 | Healthy | Phase 1 | Completed | - | United States, Wisconsin ... more >> Covance Global Clinical Research Unit Inc. Madison, Wisconsin, United States, 53704 Collapse << |
NCT01864915 | Bowel Cleansing ... more >> Colon Capsule Completion Times Collapse << | Phase 3 | Completed | - | Canada, Ontario ... more >> Hotel Dieu Hospital Kingston, Ontario, Canada, K7L 5V7 Collapse << |
NCT02047045 | Constipation | Not Applicable | Completed | - | - |
NCT00488215 | Constipation | Phase 1 | Completed | - | - |
NCT01807000 | - | - | Completed | - | - |
NCT03279341 | Chronic Constipation | Phase 4 | Completed | - | Belgium ... more >> TARGID Leuven, Belgium, 3000 Collapse << |
NCT02781493 | Prucalopride Plus Polyethylene... more >> Glycol in Bowel Preparation for Colonoscopyp Collapse << | Phase 4 | Unknown | March 2017 | China, Shandong ... more >> Department of Gastroenterology, Qilu Hospital, Shandong University Not yet recruiting Jinan, Shandong, China, 250012 Contact: Yanqing Li, MD, PhD 86-0531-82169236 liyanqing@sdu.edu.cn Collapse << |
NCT01117051 | Non-cancer Pain ... more >> Opioid Induced Constipation Collapse << | Phase 3 | Terminated(The study was stopp... more >>ed by the sponsor based on a non-safety related business priority decision) Collapse << | - | Belgium ... more >> Leuven, Belgium Collapse << |
NCT00903747 | Constipation | Phase 1 | Completed | - | - |
NCT01117051 | - | - | Terminated(The study was stopp... more >>ed by the sponsor based on a non-safety related business priority decision) Collapse << | - | - |
NCT03676374 | GERD | Phase 4 | Recruiting | April 2021 | Belgium ... more >> UZ Leuven Recruiting Leuven, Belgium, 3000 Contact: Hannelore Geysen +32 (0)16 324921 hannelore.geysen@kuleuven.be Collapse << |
NCT01674166 | Constipation | Phase 1 | Completed | - | - |
NCT02947269 | Postoperative Ileus ... more >> Colorectal Surgery Postoperative Complications Collapse << | Phase 3 | Recruiting | February 2019 | New Zealand ... more >> University of Auckland Recruiting Auckland, New Zealand, 1023 Contact: Ian Bissett, MD, FRACS +649 3737599 ext 89821 i.bissett@auckland.ac.nz Collapse << |
NCT01692132 | - | - | Withdrawn(The company decided ... more >>to cancel this study in conformity with PH FDA Circular 2013-004) Collapse << | December 2014 | Philippines ... more >> Makati City, Philippines Manila, Philippines Marikina City, Philippines Muntinlupa, Philippines Quezon City, Philippines San Juan, Philippines Taguig, Philippines Collapse << |
NCT02510976 | Gastroparesis | Phase 4 | Unknown | - | Belgium ... more >> University Hospitals Recruiting Leuven, Vlaanderen, Belgium, 3000 Contact: Jan Tack, M.D., Ph.D. +3216344225 jan.tack@med.kuleuven.be Principal Investigator: Jan Tack, M.D., Ph.D. Collapse << |
NCT02004652 | Postoperative Ileus | Phase 2 | Completed | - | China, Jiangsu ... more >> Department of Generay Surgery, Jinling hosptal, Medical School of Nanjing University Nanjing, Jiangsu, China, 210002 Collapse << |
NCT03572790 | Molecular Mechanisms of Pharma... more >>cological Action Depression Depressive Disorder Mood Disorders Mental Disorders Antidepressive Agents Cognition Collapse << | Not Applicable | Not yet recruiting | March 2020 | United Kingdom ... more >> University of Oxford Not yet recruiting Oxford, United Kingdom, OX3 7JX Collapse << |
NCT01116206 | Constipation | Phase 3 | Completed | - | Australia ... more >> Adelaide, Australia Box Hill, Australia Kingswood, Australia Kogarah, Australia Newcastle, Australia Parkville, Australia Prahran, Australia Sydney, Australia China Beijing, China Chongqing, China Guangzhou, China Hangzhou, China Hefei, China Jinan, China Nanjing, China Shanghai, China Wuhan, China Xian, China Korea, Republic of Busan, Korea, Republic of Dae-Gu, Korea, Republic of Deajun, Korea, Republic of Gwangju-Si, Korea, Republic of Iksan, Korea, Republic of Seoul, Korea, Republic of Taiwan Taipei, Taiwan Thailand Bamgkok, Thailand Bangkok, Thailand Collapse << |
NCT01674192 | Constipation | Phase 1 | Completed | - | - |
NCT01670669 | Constipation | Phase 1 | Completed | - | - |
NCT00487422 | Constipation | Phase 3 | Completed | - | - |
NCT02806206 | Gastrointestinal Hemorrhage ... more >> Crohn Disease Celiac Disease Intestinal Diseases Inflammatory Bowel Diseases Collapse << | Phase 4 | Unknown | May 2017 | Canada, British Columbia ... more >> Vancouver General Hospital Vancouver, British Columbia, Canada, V5Z 1M9 Collapse << |
靶点 | Description | IC50 |
---|---|---|
5-HT Receptor 4B | pKi:8.1 | |
5-HT Receptor 4A | pKi:8.6 |
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