|(S)-2-氨基-N-((2S,3S,4R,5R)-5-(6-(二甲胺基)-9H-嘌呤-9-基)-4-羟基-2-(羟甲基)四氢呋喃-3-基)-3-(4-甲氧基苯基)丙酰胺二盐酸盐|CsnPharm

CAS No.: 58-58-2

Puromycin dihydrochloride/嘌呤霉素二盐酸盐 Catalog No. CSN11799

Synonyms: CL13900 dihydrochloride;CL13900 2HCl;Puromycin (hydrochloride)

Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

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技术信息

生物活性

描述Puromycin (2HCl), an aminonucleoside antibiotic, inhibits protein synthesis. Puromycin (2HCl), an analog of the 3' end of aminoacyl-tRNA, causes premature termination of translation by being linked non-specifically to growing polypeptide chains. Puromycin acting as a non-inhibitor at very low concentration (e.g. 0.04 microM) can bond only to full-length protein at the C-terminus. Puromycin and its derivatives at concentrations lower than those able to compete effectively with aminoacyl-tRNA can bond specifically to full-length protein at a stop codon^[3]. Puromycin is a peptidyl nucleoside endowed with significant antibiotic and anticancer properties, but also with an unfortunate nephrotoxic character that has hampered its use as a chemotherapeutic agent^[4]. Moreover, puromycin is a damaging agent known to induce apoptosis in mammalian cells. Puromycin-induced apoptosis in S. cerevisiae^[5]. Carbocyclic puromycin was equal to puromycin when evaluated for cytotoxicity using P-388 mouse lymphoid leukemia cells in culture^[6].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
HEK239 cells	-	Cytotoxic assay	72 h	Cytotoxicity against HEK239 cells after 72 hrs by Alamar blue assay, IC50=0.42 μM.	20558060
human hepatocellular carcinoma cell line (Huh7)	-	Cytotoxic assay	-	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7), CC50=6.63 μM.	18579783
human HepG2 cells	-	Growth inhibition assay	72 h	Growth inhibition of human HepG2 cells after 72 hrs by SRB assay, IC50=0.21 μM.	18512984

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临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01132183	Healthy	Phase 1	Completed	-	India ... more >> Bioserve Clinical Research Pvt. Ltd. Hyd, Andhra Pradesh, India, 500 037 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8368 mL
- 9.1839 mL
- 18.3678 mL
- 5 mM
- 0.3674 mL
- 1.8368 mL
- 3.6736 mL
- 10 mM
- 0.1837 mL
- 0.9184 mL
- 1.8368 mL

技术信息

CAS号

58-58-2

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H31Cl2N7O5

运输

蓝冰

分子量

544.43

别名

CL13900 dihydrochloride;CL13900 2HCl;Puromycin (hydrochloride);CL 13,900;CL 16,536;NSC 3055;PDH;Puromycin Dihydrochloride;Puromycin 2HCl;嘌呤霉素二盐酸盐

溶解度

DMSO	600.0 mg/mL (1102.1 mM)
Water	100.0 mg/mL (183.7 mM)

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Puromycin dihydrochloride/嘌呤霉素二盐酸盐 Catalog No. CSN11799

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