|(8R,9S,13S,14S,17R)-3-(环戊氧基)-17-乙炔基-13-甲基-7,8,9,11,12,13,14,15,16,17-十氢-6H-环戊并[a]菲-17-醇|CsnPharm

CAS No.: 152-43-2

Quinestrol/炔雌醚 Catalog No. CSN11817

Synonyms: W-3566;Estrovis;Ethynyl Estradiol-3-cyclopentyl ether

Quinestrol is a synthetic estrogen which is used in hormone replacement therapy.

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技术信息

生物活性

描述Quinestrol is a synthetic estrogen, used in hormone replacement therapy, and occasionally to treat breast cancer and prostate cancer. The weight of epididymides and seminal vesicles decreased significantly on days 8 and 22 in quinestrol/DES-treated (Diethylstilbestrol) mice, with extensive histological changes in the seminiferous tubules. The anti-fertility effects on male mice given quinestrol were of shorter duration than for those receiving DES at the dose of 1 mg/kg body weight^[3]. Quinestrol causes reversible toxic effects in the form of oxidative stress, increased lytic enzyme activity and decreased steroidogenesis which may further lead to testicular damage thereby inhibiting reproductive function^[4]. Normal male vocal behavior during sexual interactions could be retained or even reinforced after quinestrol treatment. The treated male mice were more attractive to the female mice than the controls^[5]. The testicular weight and seminiferous tubular area gradually declined with increasing dosages of quinestrol to 50 and 100mg/kg. Rarefied germ cells showed irregular distributions in the seminiferous tubules of mice treated with 50 and 100mg/kg quinestrol. The number of germ cells expressing caspase-3, p53, Bax and FasL significantly increased whereas cells expressing Bcl-2 significantly decreased in groups treated with 50 and 100mg/kg quinestrol compared with the control. Quinestrol stimulates oxidative stress to induce apoptosis in spermatogenic cells through the mitochondrial and death receptor pathways in adult male mice^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7433 mL
- 13.7167 mL
- 27.4333 mL
- 5 mM
- 0.5487 mL
- 2.7433 mL
- 5.4867 mL
- 10 mM
- 0.2743 mL
- 1.3717 mL
- 2.7433 mL

技术信息

CAS号

152-43-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H32O2

运输

蓝冰

分子量

364.52

别名

W-3566;Estrovis;Ethynyl Estradiol-3-cyclopentyl ether;Estrovister;Plestrovis;Eston;Ethinyl;Estradiol 3 Cyclopentyl Ether;Ethinyl Estradiol 3-Cyclopentyl Ether

溶解度

DMSO	72.0 mg/mL (197.5 mM)
Water	Insoluble
Ethanol	70.0 mg/mL (192.0 mM)

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