CAS No.: 875320-29-9
Quisinostat Catalog No. CSN13126
Synonyms: JNJ-26481585
Quisinostat is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00677105 Lymphoma Neop... more >>lasms Collapse << Phase 1 Completed - United Kingdom ... more >> Glasgow, United Kingdom Leeds, United Kingdom London, United Kingdom Manchester, United Kingdom Newcastel Upon Tyne, United Kingdom Sutton, United Kingdom Collapse << NCT02728492 Non-small Cell Lung Cancer ... more >> Epithelial Ovarian Cancer Collapse << Phase 1 Completed - Russian Federation ... more >> Russian Oncological Research Center n.a. N. N. Blokhin RAMS Moscow, Russian Federation, 115478 State Budgetary Healthcare Institution of Stavropol Territory "Pyatigorsk oncology dispensary" Pyatigorsk, Russian Federation, 357502 Saint-Peterburg State Budgetary healthcare Institution "City Clinical Oncology Dispensary" Saint-Petersburg, Russian Federation, 197022 BioEq LLC Saint-Petersburg, Russian Federation, 197342 State Budget Institution of healthcare "Saint-Petersburg clinical research and practical centre of specialized medical aid (oncology)" Saint-Petersburg, Russian Federation, 197758 State Healthcare Institution of Yaroslavl region "Regional Clinical oncology hospital" Yaroslavl, Russian Federation, 150054 Collapse << NCT00676728 Advanced or Refractory Leukemi... more >>a Myelodysplastic Syndromes Collapse << Phase 1 Terminated(Sponsor Decision) - United States, Maryland ... more >> Baltimore, Maryland, United States United States, Texas Houston, Texas, United States Collapse << - 更多
- 参考文献
- [1] Jin L, Guo Q, et al. Quisinostat treatment improves histone acetylation and developmental competence of porcine somatic cell nuclear transfer embryos. Mol Reprod Dev. 2017 Apr;84(4):340-346.
- [2] Arts J, King P, et al. JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res. 2009 Nov 15;15(22):6841-51.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 875320-29-9 | 储存条件 |
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| 分子式 | C21H26N6O2 | 运输 | 蓝冰 | |
| 分子量 | 394.47 | 别名 | JNJ-26481585 |
