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CAS No.: 2022961-17-5
Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease. In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.
生物活性
实验方案
技术信息
CAS号 | 2022961-17-5 | 储存条件 |
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分子式 | C8H8Cl2N4 | 运输 | 蓝冰 | |||||||
分子量 | 231.08 | 别名 | ||||||||
溶解度 |
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动物实验配方 |
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