|(2S,5R)-5-(4-((2-氟苄基)氧基)苯基)吡咯烷-2-甲酰胺盐酸盐|CsnPharm

CAS No.: 934240-31-0

Raxatrigine HCl Catalog No. CSN15719

Synonyms: GSK-1014802 hydrochloride;CNV1014802 hydrochloride;Raxatrigine HCl

CNV1014802 HCl is a blocker of Nav1.7 sodium channel with analgesic effects.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述CNV1014802 Hydrochloride is a blocker of Nav1.7 sodium channel with analgesic effects^[3]. CNV1014802 enhances the inactivation but does not reduce the activation of Nav1.7 channels. Application of CNV1014802 (30 μmol/L) could rescue the Nav1.7 mutations expressed in CHO cells that cause paroxysmal extreme pain disorder (PEPD), thereby restoring the impaired inactivation to those of the wild-type channel^[4].
参考文献

[1] El-Mallakh RS, Elmaadawi AZ, et al. Current and emerging therapies for the management of bipolar disorders. J Cent Nerv Syst Dis. 2011 Aug 7;3:189-97.
[2] Large CH, Bison S, et al. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia. J Pharmacol Exp Ther. 2011 Jul;338(1):100-13.
[3] Obermann M. Recent advances in understanding/managing trigeminal neuralgia. F1000Res. 2019 Apr 17;8:F1000 Faculty Rev-505
[4] Zheng YM, Wang WF, Li YF, Yu Y, Gao ZB. Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802. Acta Pharmacol Sin. 2018 Apr;39(4):587-596

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8505 mL
- 14.2525 mL
- 28.5051 mL
- 5 mM
- 0.5701 mL
- 2.8505 mL
- 5.7010 mL
- 10 mM
- 0.2851 mL
- 1.4253 mL
- 2.8505 mL

技术信息

CAS号

934240-31-0

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H20ClFN2O2

运输

蓝冰

分子量

350.82

别名

GSK-1014802 hydrochloride;CNV1014802 hydrochloride;Raxatrigine HCl;GSK 1014802 HCl;Raxatrigine (hydrochloride);BIIB074;GSK1014802A;Vixotrigine;GSK-1014802;CNV-1014802;Raxatrigine

溶解度

DMSO	29.0 mg/mL (82.7 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Raxatrigine HCl Catalog No. CSN15719

靶点选择性

请登录您的专属账户

确认信息