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CAS No.: 108237-91-8

RCGD423 Catalog No. CSN25413

Synonyms: Regulator of cartilage growth and differentiation (RCGD) 423

RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.

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生物活性

实验方案

技术信息

生物活性

描述Signalling through glycoprotein 130 (gp130), the common receptor for IL-6 family cytokines, can have both context-specific and cytokine-specific effects on articular chondrocytes. RCGD423 is a small molecule gp130 modulator which can bias signalling towards anti-inflammatory and antidegenerative outputs. This small molecule increased proliferation while reducing apoptosis and hypertrophic responses in adult chondrocytes in vitro. In a rat partial meniscectomy model, RCGD423 greatly reduced chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury. Furthermore, RCGD423 improved cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage^[2]. Treatment of mice skin with 2 topical doses of RCGD423 (50uM) for 48h induced levels of both c-Myc and n-Myc as well as Ldha^[3].
参考文献

[1] Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769.
[2] Shkhyan R, Van Handel B, Bogdanov J, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018;77(5):760-769
[3] Flores A, Schell J, Krall AS, et al. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017;19(9):1017-1026

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0191 mL
- 15.0953 mL
- 30.1905 mL
- 5 mM
- 0.6038 mL
- 3.0191 mL
- 6.0381 mL
- 10 mM
- 0.3019 mL
- 1.5095 mL
- 3.0191 mL

技术信息

CAS号

108237-91-8

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H11BrN2S

运输

蓝冰

分子量

331.23

别名

Regulator of cartilage growth and differentiation (RCGD) 423

溶解度

DMSO	66.0 mg/mL (199.3 mM)
Water	Insoluble
Ethanol	32.0 mg/mL (96.6 mM)

动物实验配方

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