|rel-4,4'-((3R,4S)-己-3,4-二基)二苯酚|CsnPharm

CAS No.: 84-16-2

己烷雌酚 Catalog No. CSN11148

Synonyms: Bibenzyl;Hexoestrol;NSC 9894

Hexestrol can bind to ERα and ERβ selectively with EC50 of 0.07 nM and 0.175 nM respectively.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Hexestrol is a estrogen receptor (ER) subtype-selective ligands. Hexestrol binds to ER α and ER β with EC50 of 0.07 nm and 0.175 nm, respectively^[3]. Hexestrol inhibited akr1b13 activity with IC50 of 3.2 μ M^[4]. Hexestrol inhibited the activity of D-galactose dehydrogenase in 1-Dehydrogenase of Streptococcus thermophilus with IC50 of 0.063 mm^[5]. Hexestrol inhibited the dehydrogenase activity of akr1c20, and the IC50 of 10 μ m 4-androsten-3 α - o1-17-one was 2.7 μ M^[6]. Hexestrol inhibited 17hsd5 with IC50 of 30 μ m and tber1 with IC50 of 0.8 μ M^[7]. In mice treated with hexestrol (6 mg/kg) (Group II), ovaries were smaller than those from the controls but highly vascularized; similar results were obtained in GIV. The anabolic agent hexestrol in a high dose may decrease ovulation in mice^[8].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6987 mL
- 18.4934 mL
- 36.9869 mL
- 5 mM
- 0.7397 mL
- 3.6987 mL
- 7.3974 mL
- 10 mM
- 0.3699 mL
- 1.8493 mL
- 3.6987 mL

技术信息

CAS号

84-16-2

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H22O2

运输

蓝冰

分子量

270.37

别名

Bibenzyl;Hexoestrol;NSC 9894;Cycloestrol;Erythrohexestrol;HSDB-2149;Sinestrol

溶解度

DMSO	330.0 mg/mL (1220.6 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	6 mg/mL	clear
PO	0.5% CMC-Na	46 mg/mL	suspension

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