生物活性

• 描述Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01275170	Infectious Disease	Phase 1	Completed	-	-
  NCT02493764	Bacterial Pneumonia	Phase 3	Recruiting	May 31, 2019	-
  NCT03230916	Suspected or Documented Gram-n... more >>egative Bacterial Infection Collapse <<	Phase 1	Recruiting	August 13, 2020	United States, Arkansas ... more >> Arkansas Children's Hospital ( Site 1311) Recruiting Little Rock, Arkansas, United States, 72202 Contact: Study Coordinator    501-364-1416       United States, California Children's Hospital of Orange County ( Site 1301) Recruiting Orange, California, United States, 92868 Contact: Study Coordinator    714-509-4064       Rady Children's Hospital-San Diego ( Site 1305) Recruiting San Diego, California, United States, 92123 Contact: Study Coordinator    858-966-7785       United States, Louisiana Our Lady of the Lake Hospital ( Site 1304) Recruiting Baton Rouge, Louisiana, United States, 70808 Contact: Study Coordinator    225-765-5956       United States, North Carolina Duke University Medical Center ( Site 1317) Recruiting Durham, North Carolina, United States, 27710 Contact: Study Coordinator    919-681-1504       United States, Pennsylvania The Children's Hospital of Philadelphia ( Site 1318) Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Study Coordinator    215-590-4024       United States, Washington Seattle Childrens Hospital ( Site 1321) Recruiting Seattle, Washington, United States, 98105 Contact: Study Coordinator    206-884-5086       Colombia Fundacion Valle del Lili ( Site 0300) Recruiting Cali, Valle Del Cauca, Colombia, 760002 Contact: Study Coordinator    +57233190904022       Hospital Pablo Tobon Uribe ( Site 0301) Recruiting Medellin, Colombia, 050034 Contact: Study Coordinator    +5744459753       Hospital General de Medellin Luz Castro de Gutierrez ( Site 0303) Recruiting Medellin, Colombia, 500515 Contact: Study Coordinator    +573104902491       Norway Marie Joys Hus - Haukeland Universitetssjukehus ( Site 0902) Recruiting Bergen, Norway, 5021 Contact: Study Coordinator    +4755975200       Akershus Universitetssykehus HF ( Site 0903) Recruiting Loerenskog, Norway, 1478 Contact: Study Coordinator    +4723074587       Stavanger Universitetssykehus, Helse Stavanger ( Site 0901) Recruiting Stavanger, Norway, 4011 Contact: Study Coordinator    +4751519940       St. Olavs Hospital ( Site 0900) Recruiting Trondheim, Norway, 7006 Contact: Study Coordinator    +4772571241       Poland Wojewodzki Specjalistyczny Szpital im. Bieganskiego w Lodzi ( Site 1000) Recruiting Lodz, Poland, 91-347 Contact: Study Coordinator    +48601272443       SPZOZ im. Dzieci Warszawy w Dziekanowie Lesnym ( Site 1002) Recruiting Lomianki, Poland, 05-092 Contact: Study Coordinator    +48227657153       Ukraine Kharkiv City Children Hospital 16 ( Site 1200) Recruiting Kharkiv, Ukraine, 50082 Contact: Study Coordinator    +380662571720       Institution of Pediatr Obstetr and Gynec NAMS of Ukraine ( Site 1213) Recruiting Kyiv, Ukraine, 04050 Contact: Study Coordinator    +380444836220       Odessa Regional Children Clinical Hospital ( Site 1203) Recruiting Odesa, Ukraine, 65031 Contact: Study Coordinator    +380503169076       Zaporizhzhya Regional Clinical Childrens Hospital ( Site 1202) Recruiting Zaporizhzhya, Ukraine, 69063 Contact: Study Coordinator    +380617646726       United Kingdom University Hospital Southampton NHS Foundation Trust ( Site 1100) Recruiting Southampton, Hampshire, United Kingdom, SO16 6YD Contact: Study Coordinator    +442381206883       Bristol Royal Hospital for Children ( Site 1101) Recruiting Bristol, United Kingdom, BS2 8AF Contact: Study Coordinator    +441173427534       St. Georges University Hospital NHS Foundation Trust ( Site 1103) Recruiting London, United Kingdom, SW17 0QT Contact: Study Coordinator    +442087255382       Great Northern Children s Hospital ( Site 1102) Recruiting Newcastle, United Kingdom, NE1 4LP Contact: Study Coordinator    +441912825984 Collapse <<

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• 参考文献

• [1] Lapuebla A, Abdallah M, et al. Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City. Antimicrob Agents Chemother. 2015 Aug;59(8):5029-31.

  [2] Bush K. A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. Int J Antimicrob Agents. 2015 Nov;46(5):483-93.