|闹羊花毒素III|CsnPharm

CAS No.: 26342-66-5

Rhodojaponin III/闹羊花素 Ⅲ Catalog No. CSN20898

Synonyms: 闹羊花素 Ⅲ;红花甙Ⅲ

Rhodojaponin III is isolated from the herbs of Rhododendron molle G. Don which has antifeedant and oviposition deterrence effects against many kinds of insects.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Rhodojaponin III (R-III) is a bioactive diterpenoid isolated from the medicinal plant Rhododendron molle G. Don. Rhodojaponin III had fast oral absorption (time to peak concentration, 0.08 h) and good oral bioavailability (73.6%). In addition, rhodojaponin III was quickly eliminated after it was intravenously or orally administered, with half-life values of 0.19 and 0.76 h, respectively. After oral administration, it was widely distributed in tissues including kidney, lung, heart, spleen and thymus, but had extremely low concentrations in liver and brain^[1]. R-III strongly inhibited Sf9 cells proliferation with a time- and dose-dependent manner. R-III induced a significant dose-dependent (1, 10, 100, 200 μg/mL) increase in [Ca2+](i) and pH(i) of Sf9 cells in presence of Ca2+-containing solution (Hanks) and an irreversible decrease in the absence of extra cellular Ca2+^[2]. R-III showed an almost 30 times higher contact toxicity against third instars than for fifth instars, and the median lethal dose (LD50) values for topical application were 1.18 and 34.09 mg/kg at 72 h after treatment respectively. R-III disrupted the development of larvae to pupae or adults with median concentration for inhibiting growth (IC50) values of only 1.36 mg/L for third instars and 11.28 mg/L for fifth instars^[3].
参考文献

[1] Zhang JQ, Zhao CC, Yang QY, Liang S, Wu F, Ma BL, Feng Y. Pharmacokinetics, bioavailability and tissue distribution studies of rhodojaponin III in mice using QTRAP LC-MS/MS. Biomed Chromatogr. 2019 Nov;33(11):e4649
[2] Cheng XA, Xie JJ, Hu MY, Zhang YB, Huang JF. Induction of intracellular Ca2+ and pH changes in Sf9 insect cells by rhodojaponin-III, a natural botanic insecticide isolated from Rhododendron molle. Molecules. 2011 Apr 15;16(4):3179-96
[3] Zhong G, Liu J, Weng Q, Hu M, Luo J. Laboratory and field evaluations of rhodojaponin-III against the imported cabbage worm Pieris rapae (L.) (Lepidoptera: Pieridae). Pest Manag Sci. 2006 Oct;62(10):976-81

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7140 mL
- 13.5698 mL
- 27.1397 mL
- 5 mM
- 0.5428 mL
- 2.7140 mL
- 5.4279 mL
- 10 mM
- 0.2714 mL
- 1.3570 mL
- 2.7140 mL

技术信息

CAS号	26342-66-5	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C20H32O6	运输	蓝冰
分子量	368.46	别名	闹羊花素 Ⅲ;红花甙Ⅲ

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Rhodojaponin III/闹羊花素 Ⅲ Catalog No. CSN20898

靶点选择性

请登录您的专属账户

确认信息