CAS No.: 215174-50-8
Rimacalib Catalog No. CSN20312
Synonyms: SMP 114
SMP-114 is a CaMKII inhibitor with oral bioavailability and mediates the reduction SR Ca(2+) leak and arrhythmogenic cellular correlates.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00296257 Rheumatoid Arthritis (RA) Phase 2 Terminated - - - 参考文献
- [1] Neef S, Mann C, et al. Reduction of SR Ca(2+) leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability. Basic Res Cardiol. 2017 Jul;112(4):45.
- [2] Westra J, Brouwer E, et al. Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor. BMC Musculoskelet Disord. 2010 Mar 30;11:61.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 215174-50-8 | 储存条件 |
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| 分子式 | C22H23FN4O2 | 运输 | 蓝冰 | |
| 分子量 | 394.44 | 别名 | SMP 114 |
