|3,7-双(4-甲氧基苄基)-3,7-二氢-2H-二咪唑[4,5-d:4',5'-f][1,3]二氮杂-2-酮|CsnPharm

CAS No.: 1070773-09-9

RK-33 Catalog No. CSN19074

Synonyms: RK-33

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
A549 cells	-	Cytotoxicity assay	72 h	Cytotoxicity against human A549 cells after 72 hrs by WST1 assay, IC50=2.5 μM	21572541
A549 cells	-	Cytotoxicity assay	72 h	Cytotoxicity against human A549 cells after 72 hrs by WST1 assay, IC50=2.56 μM	23290252
H460 cells	-	Cytotoxicity assay	72 h	Cytotoxicity against human H460 cells after 72 hrs by WST1 assay, IC50=2.8 μM	21572541

更多
参考文献

[1] Xie M, Vesuna F, et al. RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3. Cancer Res. 2016 Nov 1;76(21):6340-6350. Epub 2016 Sep 12.
[2] Bol GM, Vesuna F, et al. Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. EMBO Mol Med. 2015 May;7(5):648-69.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3340 mL
- 11.6702 mL
- 23.3403 mL
- 5 mM
- 0.4668 mL
- 2.3340 mL
- 4.6681 mL
- 10 mM
- 0.2334 mL
- 1.1670 mL
- 2.3340 mL

技术信息

CAS号

1070773-09-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H20N6O3

运输

蓝冰

分子量

428.44

别名

RK-33

溶解度

DMSO	85.0 mg/mL (198.4 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

RK-33 Catalog No. CSN19074

靶点选择性

请登录您的专属账户

确认信息