|2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺|CsnPharm

CAS No.: 946387-07-1

RN-1734 Catalog No. CSN18624

Synonyms: TRPV4 Antagonist I

RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM).

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技术信息

生物活性

描述RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM)^[3]. RN-1734 clearly alleviated demyelination and inhibited glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells. In vitro, RN-1734 treatment clearly inhibited the influx of calcium and decreased the levels of IL-1β and TNF-α in lipopolysaccharide (LPS)-activated microglial cells by suppressing NF-κB P65 phosphorylation. Apoptosis of oligodendrocyte induced by LPS-activated microglia was also alleviated by RN-1734^[4]. RN-1734 inhibited the cytoplasmic calcium response to histamine in P-STS cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8304 mL
- 14.1520 mL
- 28.3039 mL
- 5 mM
- 0.5661 mL
- 2.8304 mL
- 5.6608 mL
- 10 mM
- 0.2830 mL
- 1.4152 mL
- 2.8304 mL

技术信息

CAS号

946387-07-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H22Cl2N2O2S

运输

蓝冰

分子量

353.31

别名

TRPV4 Antagonist I

溶解度

DMSO	71.0 mg/mL (201.0 mM)
Water	Insoluble
Ethanol	70.0 mg/mL (198.1 mM)

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RN-1734 Catalog No. CSN18624

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