|(2R,3R,4S,5S,6R)-2-(肉桂氧基)-6-((((2S,3R,4S,5S)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 84954-92-7

Rosavin/络塞维 Catalog No. CSN19965

Synonyms: 络塞维

Rosavin, a natural product isolated and purified from the herb of Rhodiola rosea L. with anti-fatigue effect, decreases neovascular reaction on cutaneous angiogenesis induced in mice after grafting of syngeneic tumor cells.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Rosavin is isolated from R. rosea, Rosavin shows antidepressant-like, adaptogenic, anxiolytic-like effects in mice model^[2]. Furthermore, rosavin promoted osteogenesis in bone marrow mesenchymal stem cells (BMSCs). In vivo experiments showed that treatment with rosavin could alleviate ovariectomy-induced osteoporosis in mice. Rosavin suppressed RANKL (receptor activator of nuclear factor-κB)-induced osteoclastogenesis in vivo and in vitro by blocking the NF-κB and MAPK (mitogen-activated protein kinase) pathways^[3]. Rosavin could significantly ameliorate the lung index and Pathological structure of mice with Pulmonary fibrosis by bleomycin-induced. Additionally, Rosavin could evidently decreased inflammatory cells infiltration in bronchoalveolar lavage fluid and pro-inflammatory cytokines expression in lung tissue specimens induced by bleomycin. Rosavin could down-regulate the expression of hydroxyproline and malondialdehyde and increased the activities of superoxide dismutase, glutathione peroxidase in lung tissue. The expression of Nrf2 were increased, and the expression of NF-κB p65, TGF-β1 and α-SMA were inhibited^[4].
参考文献

[1] Grech-Baran M, Sykowska-Baranek K, et al. Biotransformation of cinnamyl alcohol to rosavins by non-transformed wild type and hairy root cultures of Rhodiola kirilowii. Biotechnol Lett. 2014 Mar;36(3):649-56.
[2] Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res. 2007 Jan;21(1):37-43
[3] Zhang W, Zhang W, Huo L, Chai Y, Liu Z, Ren Z, Yu C. Rosavin suppresses osteoclastogenesis in vivo and in vitro by blocking the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Ann Transl Med. 2021 Mar;9(5):383
[4] Xin X, Yao D, Zhang K, Han S, Liu D, Wang H, Liu X, Li G, Huang J, Wang J. Protective effects of Rosavin on bleomycin-induced pulmonary fibrosis via suppressing fibrotic and inflammatory signaling pathways in mice. Biomed Pharmacother. 2019 Jul;115:108870

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3341 mL
- 11.6705 mL
- 23.3410 mL
- 5 mM
- 0.4668 mL
- 2.3341 mL
- 4.6682 mL
- 10 mM
- 0.2334 mL
- 1.1671 mL
- 2.3341 mL

技术信息

CAS号

84954-92-7

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H28O10

运输

蓝冰

分子量

428.43

别名

络塞维

溶解度

DMSO	58.0 mg/mL (135.4 mM)
Water	75.0 mg/mL (175.1 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Rosavin/络塞维 Catalog No. CSN19965

靶点选择性

请登录您的专属账户

确认信息