|(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2S,3R,4S,6R)-4-(二甲氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-14-乙基-7,12,13-三羟基-4-(((2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢-2H-吡喃-2-基)氧基)-10-(((2-甲氧基乙氧基)甲氧基)亚氨基)-3,5,7,9,11,13-六甲基氧杂环四癸-2-酮|CsnPharm

CAS No.: 80214-83-1

Roxithromycin/罗红霉素 Catalog No. CSN11870

Synonyms: RU-28965;Roxl-150;RU-965

Roxithromycin is a bacteriostatic drug acts by inhibiting protein synthesis through binding reversibly to 50S ribosomal subunits of sensitive microorganism.

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技术信息

生物活性

描述Roxithromycin is a semi-synthetic 14-membered-ring macrolide antibiotic, the in-vitro activity of roxithromycin is well documented and similar to that of other macrolide antibiotics. Roxithromycin is active against gram-positive and gram-negative cocci, gram-positive bacilli and some gram-negative bacilli, but has no significant effect on the predominant faecal flora^[3]. Roxithromycin is very well tolerated with an overall incidence of adverse events of approximately 4%. Roxithromycin has proven clinical efficacy in upper and lower respiratory infections, skin and soft tissue infections, urogenital infections and orodental infections, and appears to be as effective as more established treatments including erythromycin, amoxicillin/clavulanic acid and cefaclor^[4]. Macrolide antibiotics show antibacterial and anti-inflammatory efficacy in otitis media with effusion^[5]. The increasing of RAGE (Receptor of Advanced glycation end products) in asthmatic rats are positively correlated with airway inflammation and airway remodeling. Roxithromycin may inhibit the development of asthma by reducing the expression of RAGE^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02735707	Community-Acquired Pneumonia	Phase 4	Recruiting	June 2022	-
NCT03571230	Helicobacter Pylori Infection ... more >> Antimicrobial Susceptibility Testing Collapse <<	Phase 4	Not yet recruiting	January 30, 2020	China, Shandong ... more >> Xiuli Zuo Not yet recruiting Jinan, Shandong, China Contact: Xiuli Zuo, PhD,MD 15588818685 ext 053188369277 zuoxiuli@sina.com Sub-Investigator: Jing Liu, MD Sub-Investigator: Chaoran Ji, MD Collapse <<
NCT02819570	Premature Rupture of Membrane	Phase 4	Unknown	December 2017	Israel ... more >> Galil Medical Center Recruiting Nahariyya, Israel Contact: Maya Wolf, MD 972-507887800 homesickid@yahoo.com Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1947 mL
- 5.9734 mL
- 11.9468 mL
- 5 mM
- 0.2389 mL
- 1.1947 mL
- 2.3894 mL
- 10 mM
- 0.1195 mL
- 0.5973 mL
- 1.1947 mL

技术信息

CAS号

80214-83-1

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C41H76N2O15

运输

蓝冰

分子量

837.05

别名

RU-28965;Roxl-150;RU-965;Rulide;罗红霉素

溶解度

DMSO	100.0 mg/mL (119.5 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02735707	Community-Acquired Pneumonia	Phase 4	Recruiting	June 2022	-
NCT03571230	Helicobacter Pylori Infection ... more >> Antimicrobial Susceptibility Testing Collapse <<	Phase 4	Not yet recruiting	January 30, 2020	China, Shandong ... more >> Xiuli Zuo Not yet recruiting Jinan, Shandong, China Contact: Xiuli Zuo, PhD,MD 15588818685 ext 053188369277 zuoxiuli@sina.com Sub-Investigator: Jing Liu, MD Sub-Investigator: Chaoran Ji, MD Collapse <<
NCT02819570	Premature Rupture of Membrane	Phase 4	Unknown	December 2017	Israel ... more >> Galil Medical Center Recruiting Nahariyya, Israel Contact: Maya Wolf, MD 972-507887800 homesickid@yahoo.com Collapse <<
NCT02469298	Virus Diseases	Phase 2	Completed	-	-
NCT00285493	Low Back Pain	Phase 1	Withdrawn(Withdrawn study halt... more >>ed prematurely, prior to enrollment of first participant) Collapse <<	-	-
NCT03148444	Infection, Bacterial ... more >> Pacemaker Complication Collapse <<	Phase 4	Not yet recruiting	June 1, 2020	-
NCT02469298	-	-	Completed	-	-
NCT01843946	-	-	Completed	-	Korea, Republic of ... more >> The Catholic University of Korea, St. Vincent's Hospital Suwon, Korea, Republic of, 442-723 Collapse <<
NCT03414918	Hyperaldosteronism	Not Applicable	Not yet recruiting	January 2020	Italy ... more >> Department of Medicine - DIMED, University of Padova, Italy Not yet recruiting Padova, Italy Principal Investigator: Gian Paolo Rossi, MD Collapse <<
NCT00621387	Reactive Arthritis	Not Applicable	Completed	-	Finland ... more >> Division of Rheumatology, Department of Medicine Helsinki, Finland, 00029 Peijas Hospital Vantaa, Finland, 01400 Collapse <<
NCT00197379	Alopecia	Not Applicable	Unknown	January 2007	Japan ... more >> Department of Dermatology, Hamamatsu University School of Medicine Hamamatsu, Japan, 431-3192 Collapse <<
NCT03565484	Helicobacter Pylori Infection	Phase 4	Not yet recruiting	April 30, 2020	China, Shandong ... more >> Qilu hosipital Not yet recruiting Jinan, Shandong, China, 257000 Contact: Xiuli Zuo, MD,PhD 15588818685 ext 053188369277 zuoxiuli@sina.com Sub-Investigator: Chaoran Ji, MD Sub-Investigator: Jing Liu, MD Collapse <<
NCT00439062	Rheumatoid Arthritis	Phase 4	Completed	-	Turkey ... more >> Nazilli State Hospital Nazilli, Aydin, Turkey, 09800 Collapse <<

Roxithromycin/罗红霉素 Catalog No. CSN11870

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