CAS No.: 668463-35-2
RPR-260243 Catalog No. CSN15798
RPR-260243 is an activator of HERG which modifies HERG currents inhibited by dofetilide (IC50 = 58 nM) and shows little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Wu W, Gardner A, Sanguinetti MC. Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243. Mol Pharmacol. 2015;87(3):401-9.
- [2] Kang J, Chen XL, et al. Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. Mol Pharmacol. 2005 Mar;67(3):827-36.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 668463-35-2 | 储存条件 |
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| 分子式 | C28H25F3N2O4 | 运输 | 蓝冰 | |
| 分子量 | 510.50 | 别名 |
