|(1S,3R)-2-(2-氯乙酰基)-1-(4-(甲氧羰基)苯基)-2,3,4,9-四氢-1H-吡啶[3,4-b]吲哚-3-羧酸甲酯|CsnPharm

CAS No.: 1219810-16-8

RSL3 Catalog No. CSN17581

Synonyms: (1S,3R)-RSL3

RSL3 is a ferroptosis activator in a VDAC-independent manner, exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述RSL3 is a VDAC-independent ferroptosis activator, which may target on GPX4. RSL3 inhibited cell viability of BJ-derived cell lines at various concentration for the RAS-RAF-MEK pathway could cause RSL3 sensitivity.
作用机制RSL3 can react with the eight nucleophilic amino axide residues of GPX4
动物研究
剂量
Mice: 100 mg/kg^[3] (intratumoral); 100 mg/kg^[4] (s.c.)

给药途径
Intratumoral (twice per week for 20 days), s.c.
参考文献

动物研究
剂量	Mice: 100 mg/kg^[3] (intratumoral); 100 mg/kg^[4] (s.c.)
给药途径	Intratumoral (twice per week for 20 days), s.c.

[1] Dachert J, Schoeneberger H, et al. RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death. Oncotarget. 2016 Sep 27;7(39):63779-63792.
[2] Yang WS, Stockwell BR, et al. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008 Mar;15(3):234-45.
[3] Bi J, Yang S, et al. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis. 2019 Sep 17;10(10):682.
[4] Yang WS, SriRamaratnam R, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16;156(1-2):317-331.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2682 mL
- 11.3410 mL
- 22.6821 mL
- 5 mM
- 0.4536 mL
- 2.2682 mL
- 4.5364 mL
- 10 mM
- 0.2268 mL
- 1.1341 mL
- 2.2682 mL

技术信息

CAS号

1219810-16-8

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H21ClN2O5

运输

蓝冰

分子量

440.88

别名

(1S,3R)-RSL3

溶解度

DMSO	195.0 mg/mL (442.3 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	2.4 mg/mL	clear
PO	0.5% CMC-Na	28 mg/mL	suspension

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RSL3 Catalog No. CSN17581

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