CAS No.: 472-11-7
Ruscogenin/鲁斯可皂苷元 Catalog No. CSN19963
Synonyms: 鲁斯可皂苷元
Ruscogenin, a natural product isolated and purified from the root of Ophiopogon japonicus with significant anti-inflammatory and anti-thrombotic activities, significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, protects the brain against ischemic damage caused by middle cerebral artery occlusion (MCAO) which may be through downregulation of NF-κB-mediated inflammatory responses, inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways, and may attenuate high-fat diet (HFD)-induced steatohepatitis through downregulation of NF- κB-mediated inflammatory responses, reducing hepatic lipogenic gene expression, and upregulating proteins in β-oxidation pathway.
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tech@csnpharm.cn靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01984931 Nausea Vomiti... more >>ng Collapse << Phase 3 Unknown December 2013 Korea, Republic of ... more >> Chungmu General Hopsital Recruiting Seoul, Yeongdeungpo-gu, Korea, Republic of, 150-034 Contact: Sang Hoon Lhee, MD, Phd +82 (2) 2068/4525 cmirb@naver.com Principal Investigator: Paolo Alan B Tabar, MD Collapse << - 参考文献
- [1] Ji PY, Li ZW, et al. Rapid determination of ruscogenin in rat plasma with application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:71-4.
- [2] Lu HJ, Liou SS, et al. Ruscogenin protects against high-fat diet-induced nonalcoholic steatohepatitis in hamsters. Planta Med. 2014 Jul;80(11):870-9.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 472-11-7 | 储存条件 |
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| 分子式 | C27H42O4 | 运输 | 蓝冰 | |
| 分子量 | 430.62 | 别名 | 鲁斯可皂苷元 |
