|2-(3,4-二羟基苯基)-5,7-二羟基-3-((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(((((2R,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 153-18-4

Rutin/芦丁 Catalog No. CSN16175

Synonyms: Rutoside;Quercetin 3-O-rutinoside;Birutan

Rutin, a flavonol glycoside, has vitamin P-like and anti-inflammatory effects which can be found in many plants including buckwheat, tobacco, forsythia, hydrangea, viola, etc..

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Rutin is a multifunctional natural flavonoid glycoside found in many plants and shows a wide range of biological activities including anti-inflammatory, antioxidant, neuroprotective, nephroprotective, and hepatoprotective effects^[3]. From UV-Vis spectrophotometric measurements the acidity constants of Rutin in aqueous media, at 25 °C and 0.1 M ionic strength, pK1 = 4.392 ± 0.167, pK2 = 7.130 ± 0.050. Moreover, the bare CPE was used for the electrochemical quantification of Rutin in neutral aqueous media, displaying the following features: (1.078 ± 0.440) μM, (3.594 ± 0.400) μM and (0.308 ± 0.014) μM^[4].Oral administration of 50 or 100 mg/kg of rutin significantly decreased fasting blood glucose (FBG) and HbA1c levels^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03569930	Hemorrhoids	Phase 4	Active, not recruiting	May 1, 2019	Italy ... more >> Department of General Surgery "Paride Stefanini", University of Rome "La Sapienza" Rome, RM, Italy, 00161 Collapse <<
NCT01271218	Knee Osteoarthritis	Phase 4	Completed	-	United States, Texas ... more >> Exercise & Sport Nutrition Lab College Station, Texas, United States, 78843 Collapse <<
NCT03444623	-	-	Completed	-	-

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参考文献

[1] Navarro-Nunez L, Lozano ML, et al. Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway. J Agric Food Chem. 2008 May 14;56(9):2970-6.
[2] Ortolani O, Caggiano M, et al. Protection from ischemia-reperfusion damage in patients with stroke: the role of rutin and GSH. Transplant Proc. 1995 Oct;27(5):2877-8.
[3] Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017 Dec;96:305-312. doi: 10.1016/j.biopha.2017.10.001. Epub 2017 Oct 7. PMID: 29017142.
[4] Guzmán-Hernández DS, Palomar-Pardavé M, Sánchez-Pérez F, Juárez-Gómez J, Corona-Avendaño S, Romero-Romo M, Ramírez-Silva MT. Spectro-electrochemical characterization and quantification of Rutin in aqueous media. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Mar 5;228:117814. doi: 10.1016/j.saa.2019.117814. Epub 2019 Nov 20. PMID: 31780308.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6379 mL
- 8.1897 mL
- 16.3795 mL
- 5 mM
- 0.3276 mL
- 1.6379 mL
- 3.2759 mL
- 10 mM
- 0.1638 mL
- 0.8190 mL
- 1.6379 mL

技术信息

CAS号

153-18-4

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H30O16

运输

蓝冰

分子量

610.52

别名

Rutoside;Quercetin 3-O-rutinoside;Birutan;Eldrin;Oxyritin;Paliuroside;Sophorin;Venoruton;Yunxianggan;芦丁

溶解度

DMSO	140.0 mg/mL (229.3 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03569930	Hemorrhoids	Phase 4	Active, not recruiting	May 1, 2019	Italy ... more >> Department of General Surgery "Paride Stefanini", University of Rome "La Sapienza" Rome, RM, Italy, 00161 Collapse <<
NCT01271218	Knee Osteoarthritis	Phase 4	Completed	-	United States, Texas ... more >> Exercise & Sport Nutrition Lab College Station, Texas, United States, 78843 Collapse <<
NCT03444623	-	-	Completed	-	-
NCT00330096	Osteoporosis, Osteopenia	Phase 3	Completed	-	France ... more >> Centre de Recherche en Nutrition Humaine. Laboratoire de Nutrition Humaine Clermont-Ferrand, Auvergne, France, 63009 Collapse <<
NCT03577145	Healthy Adults	Not Applicable	Recruiting	March 31, 2019	United Kingdom ... more >> School of Medicine, Nursing and Dentistry, College of MVLS, University of Glasgow Recruiting Glasgow, Lanarkshire, United Kingdom, G31 2ER Contact: Christine Edwards, PhD 01412018685 Christine.Edwards@glasgow.ac.uk Contact: Emilie Combet Aspray, PhD 01412018527 Emilie.CombetAspray@glasgow.ac.uk Collapse <<
NCT00864578	-	-	Withdrawn(loss of interest bef... more >>ore enrolment started) Collapse <<	June 2009	Italy ... more >> Ophthalmology Department of the University Clinic Bari, Italy, I-70124 Collapse <<
NCT00003365	Colorectal Cancer	Not Applicable	Terminated(Study completed)	-	United States, New York ... more >> Rockefeller University Hospital New York, New York, United States, 10021-6399 Collapse <<
NCT00863811	-	-	Withdrawn(loss of interest bef... more >>ore enrolment started) Collapse <<	July 2009	Italy ... more >> Ophthalmology Department of the University Bari, Italy, I-70124 Collapse <<
NCT03470337	Thrombophlebitis Leg	Phase 3	Completed	-	Italy ... more >> Dr. Baumueller Fano, Italy, 61032 Collapse <<
NCT01254006	Glaucoma	Not Applicable	Completed	-	Italy ... more >> Univerisity La Sapienza Latina, Italy Collapse <<
NCT01847521	Autism Spectrum Disorders	Phase 2	Completed	-	Greece ... more >> Attikon Hospital Chaidari, Athens, Greece, 124 62 Collapse <<
NCT03437902	Type 2 Diabetes Mellitus	Phase 2 Phase 3	Completed	-	Egypt ... more >> Ain Shams University Cairo, Egypt Collapse <<
NCT00002311	HIV Infections	Phase 1	Completed	-	United States, New York ... more >> Saint Luke's - Roosevelt Hosp Ctr New York, New York, United States, 10019 Collapse <<

Rutin/芦丁 Catalog No. CSN16175

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