CAS No.: 941685-37-6
Ruxolitinib (S enantiomer) Catalog No. CSN18612
Synonyms: S-Ruxolitinib;S-INCB18424;INCB 018424 S-Enantiomer
S-Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, > 130-fold selectivity for JAK1/2 versus JAK3.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Verstovsek S, Mesa RA, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012 Mar 1;366(9):799-807.
- [2] Quintas-Cardama A, Vaddi K, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood. 2010 Apr 15;115(15):3109-17.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 941685-37-6 | 储存条件 |
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| 分子式 | C17H18N6 | 运输 | 蓝冰 | |
| 分子量 | 306.37 | 别名 | S-Ruxolitinib;S-INCB18424;INCB 018424 S-Enantiomer;Ruxolitinib S-Enantiomer;(S)-INCB018424 |
