生物活性

• 描述RX-3117 is a cytidine analog showing anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02030067	Solid Tumor M... more >>etastatic Bladder Cancer Collapse <<	Phase 1 Phase 2	Recruiting	December 2018	United States, Alabama ... more >> Rexahn Site Completed Birmingham, Alabama, United States, 35294 United States, Arizona Rexahn Site Recruiting Tucson, Arizona, United States, 85724 United States, California Rexahn Site Recruiting Duarte, California, United States, 91010 United States, Florida Rexahn Site Completed Miami Lakes, Florida, United States, 33014 Rexahn Site Active, not recruiting Miami, Florida, United States, 33136 United States, Illinois Rexahn Site Completed Skokie, Illinois, United States, 60077 United States, Missouri Rexahn Site Recruiting Saint Louis, Missouri, United States, 63110 United States, Nevada Rexahn Site Completed Las Vegas, Nevada, United States, 89119 United States, New York Rexahn Site Recruiting New York, New York, United States, 10021 United States, Texas Rexahn Site Completed San Antonio, Texas, United States, 78229 United States, Utah Rexahn Site Recruiting Salt Lake City, Utah, United States, 84112 United States, Virginia Rexahn Site Completed Fairfax, Virginia, United States, 22031 Collapse <<
  NCT03189914	Metastatic Pancreatic Cancer	Phase 1 Phase 2	Recruiting	July 2020	United States, Arizona ... more >> Rexahn Site Recruiting Tucson, Arizona, United States, 85724 United States, Florida Rexahn Site Recruiting Weeki Wachee, Florida, United States, 34607 United States, Illinois Rexahn Site Recruiting Joliet, Illinois, United States, 60435 Rexahn Site Recruiting Skokie, Illinois, United States, 60077 United States, Kentucky Rexahn Site Recruiting Lexington, Kentucky, United States, 40503 United States, Massachusetts Rexahn Site Recruiting Boston, Massachusetts, United States, 02115 United States, New York Rexahn Site Recruiting New York, New York, United States, 10065 United States, South Carolina Rexahn Site Recruiting Spartanburg, South Carolina, United States, 29303 United States, Texas Rexahn Site Recruiting Arlington, Texas, United States, 76012 United States, Washington Rexahn Site Recruiting Spokane, Washington, United States, 99202 United States, Wisconsin Rexahn Site Recruiting Milwaukee, Wisconsin, United States, 53226 Collapse <<

• 参考文献

• [1] Yang MY, Lee YB, et al. A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine. Anticancer Res. 2014 Dec;34(12):6951-9.

  [2] Peters GJ, Smid K, et al. Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine(RX-3117; TV-1360). Invest New Drugs. 2013 Dec;31(6):1444-57.