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CAS No.: 2252262-24-9

Sabatolimab/Sabatolimab抗体 Catalog No. CSN79696

Synonyms: MBG453

Sabatolimab is a humanized monoclonal antibody (hIgG4, S228P) directed against human T-cell immunoglobulin domain and mucin domain-3 (TIM-3).

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描述Sabatolimab is a humanized monoclonal antibody (hIgG4, S228P) directed against human T-cell immunoglobulin domain and mucin domain-3 (TIM-3). Sabatolimab was tested for binding to its target TIM-3 and blocking properties. The functional effects of sabatolimab were tested in T-cell killing and myeloid cell cytokine assays. Sabatolimab was shown to (i) enhance T-cell killing and inflammatory cytokine production by dendritic cells (DCs); (ii) facilitate the phagocytic uptake of TIM-3-expressing target cells; and (iii) block the interaction between TIM-3 and its ligands PtdSer/galectin-9^[1].

Product Name: Sabatolimab
Reactivities: Human
Target: TIM-3
Recommended Dilution Buffer: PBS, pH 7.4. Contains no stabilizers or preservatives.
Formulation: PBS, pH 7.4. Contains no stabilizers or preservatives.
Endotoxin: <1 EU/mg. Determined by LAL gel clotting assay.
Purity: >95%. Determined by SDS-PAGE.
Sterility: 0.2 μM filtered
Expression System: CHO
Purification: Protein A
Storage: 2 weeks, 2-8℃ under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage.
BioIsotype: Human IgG4(S228P)-Kappa
Bio Recommend Isotype Controls: Anti-HEL Human IgG4 (S228P)-Kappa Isotype control
参考文献

[1] Schwartz S, Patel N, Longmire T, Jayaraman P, Jiang X, Lu H, Baker L, Velez J, Ramesh R, Wavreille AS, Verneret M, Fan H, Hu T, Xu F, Taraszka J, Pelletier M, Miyashiro J, Rinne M, Dranoff G, Sabatos-Peyton C, Cremasco V. Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor. Immunother Adv. 2022 Aug 10;2(1):ltac019. doi: 10.1093/immadv/ltac019. Erratum in: Immunother Adv. 2023 Feb 18;3(1):ltad002. PMID: 36196369; PMCID: PMC9525012.

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CAS号	2252262-24-9		储存条件	粉末 Sealed in dry,under -80°C 液体 -20°C:3-6 月 -80°C:12月
分子式			运输	蓝冰
分子量	N/A		别名	MBG453

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