|(R)-3-(3,4-二羟基苯基)-2-((E)-3-(2-((E)-3,4-二羟基苯乙烯基)-3,4-二羟基苯基)丙烯酰基)氧基)丙酸|CsnPharm

CAS No.: 96574-01-5

Salvianolic acid A/丹酚酸A Catalog No. CSN16901

Synonyms: FS73769;Salvianolic Acid-A;Dan Phenolic Acid A

Salvianolic acid A, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant and protective activity, significantly improves glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats, inhibits platelet activation via the inhibition of PI3K, and attenuates arterial thrombus formation in vivo, suggesting that it may be developed as a therapeutic agent for the prevention of thrombotic disorders. Salvianolic acid A is also a matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats, and inhibits PDGF-BB-activated HSC proliferation, partially through apoptosis induction while exerting no direct cytotoxicity on primary hepatocytes and HSC-T6 cells under experimental concentrations.

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生物活性

描述Salvianolic acid A (Sal A or SAA) is a hydrophilic polyphenolic derivative isolated from Salvia miltiorrhiza Bunge as an anti-cancer and cardio-protective herbal medicine. The IC50 values were determined as 5.7 µM in the HEK293/ETAR cell line and 3.14 µM in HeLa cells, respectively^[3]. in vitro, SAA enhances the activation of the Akt/GSK-3β/Nrf2 signaling pathway in H2O2-Induced HK-2 Cells. in vivo, administration of SAA significantly increased the activities of T-SOD, GPx, and CAT^[4]. It also can inhibit platelet activation via the inhibition of PI3K, and attenuates arterial thrombus formation in vivo, suggesting that it may be developed as a therapeutic agent for the prevention of thrombotic disorders^[5]. Salvianolic acid A is also a matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats, and inhibits PDGF-BB-activated HSC proliferation, partially through apoptosis induction while exerting no direct cytotoxicity on primary hepatocytes and HSC-T6 cells under experimental concentrations^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02870764	Angina, Stable ... more >> Inflammation Collapse <<	Phase 4	Unknown	August 2017	China, Jiangsu ... more >> Taizhou Fourth People's Hospital Recruiting Taizhou, Jiangsu, China, 225300 Contact: Bailing Su, MD 0086052380185012 tzsybgs055@sina.com Contact: Haoshen Wang, MD 008613952613616 billet1116@163.com Collapse <<
NCT03306550	Angina, Stable	Not Applicable	Not yet recruiting	October 10, 2018	-
NCT01761227	Vascular Dementia	Phase 2	Completed	-	China, Beijing ... more >> Dongzhimen Hospital ,Beijing University of Chinese Medicine Beijing, Beijing, China, 100700 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0225 mL
- 10.1123 mL
- 20.2246 mL
- 5 mM
- 0.4045 mL
- 2.0225 mL
- 4.0449 mL
- 10 mM
- 0.2022 mL
- 1.0112 mL
- 2.0225 mL

技术信息

CAS号

96574-01-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H22O10

运输

蓝冰

分子量

494.45

别名

FS73769;Salvianolic Acid-A;Dan Phenolic Acid A;丹酚酸 A

溶解度

DMSO	71.0 mg/mL (143.6 mM)
Water	38.0 mg/mL (76.9 mM)

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