400-920-2911 sales@csnpharm.cn
您的位置 : 首页 / PI3K/Akt/mTOR / mTOR / Sapanisertib/沙帕色替
CAS No.: 1224844-38-5
Synonyms: INK-128;MLN0128;TAK-228
INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM and is > 200-fold less potent to class I PI3K isoforms.
生物活性
靶点 | mTOR IC50:1nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT02159989 | Advanced Malignant Solid Neopl... more >>asm Fibrolamellar Carcinoma Metastatic Malignant Solid Neoplasm Ovarian Carcinoma Pancreatic Neuroendocrine Tumor Recurrent Malignant Solid Neoplasm Refractory Malignant Solid Neoplasm Unresectable Solid Neoplasm Collapse << | Phase 1 | Recruiting | - | United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Aung Naing 713-792-3245 Principal Investigator: Aung Naing Collapse << |
NCT02601209 | High Grade Sarcoma ... more >> Metastatic Leiomyosarcoma Metastatic Malignant Peripheral Nerve Sheath Tumor Metastatic Synovial Sarcoma Metastatic Undifferentiated Pleomorphic Sarcoma Myxofibrosarcoma Recurrent Leiomyosarcoma Recurrent Malignant Peripheral Nerve Sheath Tumor Recurrent Synovial Sarcoma Recurrent Undifferentiated Pleomorphic Sarcoma Stage III Uterine Corpus Leiomyosarcoma AJCC v8 Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8 Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8 Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8 Stage IV Uterine Corpus Leiomyosarcoma AJCC v8 Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8 Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8 Collapse << | Phase 1 Phase 2 | Active, not recruiting | - | - |
NCT02417701 | KEAP1 Gene Mutation ... more >> KRAS Gene Mutation NFE2L2 Gene Mutation Recurrent Squamous Cell Lung Carcinoma Stage IV Squamous Cell Lung Carcinoma AJCC v7 Collapse << | Phase 2 | Recruiting | - | United States, New Jersey ... more >> Memorial Sloan Kettering Basking Ridge Recruiting Basking Ridge, New Jersey, United States, 07920 Contact: Sree B. Chalasani 212-639-7592 Sub-Investigator: Sree B. Chalasani Sub-Investigator: Loren S. Michel Sub-Investigator: Han Xiao Sub-Investigator: Afsheen Iqbal Memorial Sloan Kettering Monmouth Recruiting Middletown, New Jersey, United States, 07748 Contact: Azadeh Namakydoust 212-639-7592 Sub-Investigator: Azadeh Namakydoust Sub-Investigator: Jason A. Konner Sub-Investigator: Colette N. Owens Sub-Investigator: Serena T. Wong Sub-Investigator: Marina Shcherba United States, New York Memorial Sloan Kettering Commack Recruiting Commack, New York, United States, 11725 Contact: Jia Li 212-639-7592 Sub-Investigator: Jia Li Sub-Investigator: Jahan Aghalar Sub-Investigator: Avni M. Desai Sub-Investigator: Juliana W. Eng Sub-Investigator: John J. Fiore Sub-Investigator: Stuart M. Lichtman Sub-Investigator: Wanqing I. Zhi Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Daniel C. McFarland 212-639-7592 Sub-Investigator: Daniel C. McFarland Sub-Investigator: Parisa Momtaz Sub-Investigator: Alice Zervoudakis Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Paul K. Paik 646-888-4202 paikp@mskcc.org Principal Investigator: Paul K. Paik Memorial Sloan Kettering Rockville Centre Recruiting Rockville Centre, New York, United States, 11570 Contact: Arlyn J. Apollo 212-639-7592 Sub-Investigator: Arlyn J. Apollo Sub-Investigator: Pamela R. Drullinsky Sub-Investigator: Zoe Goldberg Sub-Investigator: Tiffany Troso-Sandoval Collapse << |
实验方案
技术信息
CAS号 | 1224844-38-5 | 储存条件 |
|
|||||||||||||
分子式 | C15H15N7O | 运输 | 蓝冰 | |||||||||||||
分子量 | 309.33 | 别名 | INK-128;MLN0128;TAK-228;沙帕色替 | |||||||||||||
溶解度 |
|
动物实验配方 |
|
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
---|
MIA PaCa-2 | 1-100 nM | Cell Viability Assay | 72 h | inhibits cell viability dose dependently | 24971544 |
PANC-1 | 1-100 nM | Cell Viability Assay | 72 h | inhibits cell viability dose dependently | 24971544 |
PANC-1 | 50 nM | Cell Viability Assay | 24-96 h | inhibits cell viability time dependently | 24971544 |
PANC-1 | 10-100 nM | Apoptosis Assay | 72 h | induces apoptosis dose dependently | 24971544 |
PANC-1 | 10/50 nM | Function Assay | 24 h | dramatically inhibits phosphorylation of 4E-BP1-S6K1 (mTORC1 activation indicators) and Akt at Ser 473 (the mTORC2 activation indicator) | 24971544 |
PANC-1 | 50 nM | Function Assay | 48 h | disrupts cell cycle progression | 24971544 |
PANC-1 | 10 nM | Function Assay | 72 h | increases gemcitabine sensitivity | 24971544 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02159989 | Advanced Malignant Solid Neopl... more >>asm Fibrolamellar Carcinoma Metastatic Malignant Solid Neoplasm Ovarian Carcinoma Pancreatic Neuroendocrine Tumor Recurrent Malignant Solid Neoplasm Refractory Malignant Solid Neoplasm Unresectable Solid Neoplasm Collapse << | Phase 1 | Recruiting | - | United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Aung Naing 713-792-3245 Principal Investigator: Aung Naing Collapse << |
NCT02601209 | High Grade Sarcoma ... more >> Metastatic Leiomyosarcoma Metastatic Malignant Peripheral Nerve Sheath Tumor Metastatic Synovial Sarcoma Metastatic Undifferentiated Pleomorphic Sarcoma Myxofibrosarcoma Recurrent Leiomyosarcoma Recurrent Malignant Peripheral Nerve Sheath Tumor Recurrent Synovial Sarcoma Recurrent Undifferentiated Pleomorphic Sarcoma Stage III Uterine Corpus Leiomyosarcoma AJCC v8 Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8 Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8 Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8 Stage IV Uterine Corpus Leiomyosarcoma AJCC v8 Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8 Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8 Collapse << | Phase 1 Phase 2 | Active, not recruiting | - | - |
NCT02417701 | KEAP1 Gene Mutation ... more >> KRAS Gene Mutation NFE2L2 Gene Mutation Recurrent Squamous Cell Lung Carcinoma Stage IV Squamous Cell Lung Carcinoma AJCC v7 Collapse << | Phase 2 | Recruiting | - | United States, New Jersey ... more >> Memorial Sloan Kettering Basking Ridge Recruiting Basking Ridge, New Jersey, United States, 07920 Contact: Sree B. Chalasani 212-639-7592 Sub-Investigator: Sree B. Chalasani Sub-Investigator: Loren S. Michel Sub-Investigator: Han Xiao Sub-Investigator: Afsheen Iqbal Memorial Sloan Kettering Monmouth Recruiting Middletown, New Jersey, United States, 07748 Contact: Azadeh Namakydoust 212-639-7592 Sub-Investigator: Azadeh Namakydoust Sub-Investigator: Jason A. Konner Sub-Investigator: Colette N. Owens Sub-Investigator: Serena T. Wong Sub-Investigator: Marina Shcherba United States, New York Memorial Sloan Kettering Commack Recruiting Commack, New York, United States, 11725 Contact: Jia Li 212-639-7592 Sub-Investigator: Jia Li Sub-Investigator: Jahan Aghalar Sub-Investigator: Avni M. Desai Sub-Investigator: Juliana W. Eng Sub-Investigator: John J. Fiore Sub-Investigator: Stuart M. Lichtman Sub-Investigator: Wanqing I. Zhi Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Daniel C. McFarland 212-639-7592 Sub-Investigator: Daniel C. McFarland Sub-Investigator: Parisa Momtaz Sub-Investigator: Alice Zervoudakis Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Paul K. Paik 646-888-4202 paikp@mskcc.org Principal Investigator: Paul K. Paik Memorial Sloan Kettering Rockville Centre Recruiting Rockville Centre, New York, United States, 11570 Contact: Arlyn J. Apollo 212-639-7592 Sub-Investigator: Arlyn J. Apollo Sub-Investigator: Pamela R. Drullinsky Sub-Investigator: Zoe Goldberg Sub-Investigator: Tiffany Troso-Sandoval Collapse << |
NCT02465060 | Advanced Malignant Solid Neopl... more >>asm Bladder Carcinoma Breast Carcinoma Cervical Carcinoma Colon Carcinoma Colorectal Carcinoma Endometrial Carcinoma Esophageal Carcinoma Gastric Carcinoma Glioma Head and Neck Carcinoma Kidney Carcinoma Liver and Intrahepatic Bile Duct Carcinoma Lung Carcinoma Lymphoma Malignant Uterine Neoplasm Melanoma Ovarian Carcinoma Pancreatic Carcinoma Plasma Cell Myeloma Prostate Carcinoma Rectal Carcinoma Recurrent Bladder Carcinoma Recurrent Breast Carcinoma Recurrent Cervical Carcinoma Recurrent Colon Carcinoma Recurrent Colorectal Carcinoma Recurrent Esophageal Carcinoma Recurrent Gastric Carcinoma Recurrent Glioma Recurrent Head and Neck Carcinoma Recurrent Liver Carcinoma Recurrent Lung Carcinoma Recurrent Lymphoma Recurrent Malignant Solid Neoplasm Recurrent Melanoma Recurrent Ovarian Carcinoma Recurrent Pancreatic Carcinoma Recurrent Plasma Cell Myeloma Recurrent Prostate Carcinoma Recurrent Rectal Carcinoma Recurrent Skin Carcinoma Recurrent Thyroid Gland Carcinoma Recurrent Uterine Corpus Carcinoma Refractory Lymphoma Refractory Malignant Solid Neoplasm Refractory Plasma Cell Myeloma Skin Carcinoma Thyroid Gland Carcinoma Uterine Corpus Cancer Collapse << | Phase 2 | Recruiting | - | - |
NCT02893930 | Pancreatic Neuroendocrine Tumo... more >>r G1 Pancreatic Neuroendocrine Tumor G2 Refractory Pancreatic Neuroendocrine Carcinoma Collapse << | Phase 2 | Suspended(Scheduled Interim Mo... more >>nitoring) Collapse << | August 1, 2019 | - |
NCT02503722 | EGFR Activating Mutation ... more >> EGFR Exon 19 Deletion Mutation EGFR NP_005219.2:p.G719X EGFR NP_005219.2:p.L858R EGFR NP_005219.2:p.L861Q EGFR T790M Mutation Negative Recurrent Non-Small Cell Lung Carcinoma Stage III Non-Small Cell Lung Cancer AJCC v7 Stage IIIA Non-Small Cell Lung Cancer AJCC v7 Stage IIIB Lung Non-Small Cell Cancer AJCC v7 Stage IV Non-Small Cell Lung Cancer AJCC v7 Collapse << | Phase 1 | Recruiting | - | United States, Connecticut ... more >> Smilow Cancer Center/Yale-New Haven Hospital Suspended New Haven, Connecticut, United States, 06510 Yale University Suspended New Haven, Connecticut, United States, 06520 United States, Florida Moffitt Cancer Center Recruiting Tampa, Florida, United States, 33612 Contact: Site Public Contact 800-456-7121 canceranswers@moffitt.org Principal Investigator: Eric B. Haura Canada, British Columbia BCCA-Vancouver Cancer Centre Recruiting Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Site Public Contact 888-939-3333 Principal Investigator: Cheryl Ho Canada, Ontario University Health Network-Princess Margaret Hospital Recruiting Toronto, Ontario, Canada, M5G 2M9 Contact: Site Public Contact 416-946-4501 clinical.trials@uhn.on.ca Principal Investigator: Penelope A. Bradbury Collapse << |
NCT02484430 | Acute Lymphoblastic Leukemia i... more >>n Remission B Acute Lymphoblastic Leukemia B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative Blasts 10 Percent or More of Bone Marrow Nucleated Cells Recurrent Adult Acute Lymphoblastic Leukemia Refractory Adult Acute Lymphoblastic Leukemia T Acute Lymphoblastic Leukemia Collapse << | Phase 2 | Suspended(Other - evaluate stu... more >>dy endpoints for the interim analysis) Collapse << | - | United States, Arizona ... more >> Mayo Clinic Hospital Phoenix, Arizona, United States, 85054 Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, California City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 Los Angeles County-USC Medical Center Los Angeles, California, United States, 90033 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 United States, District of Columbia MedStar Georgetown University Hospital Washington, District of Columbia, United States, 20007 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Kansas University of Kansas Clinical Research Center Fairway, Kansas, United States, 66205 University of Kansas Cancer Center Kansas City, Kansas, United States, 66160 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Utah Huntsman Cancer Institute/University of Utah Salt Lake City, Utah, United States, 84112 Collapse << |
NCT03047213 | Metastatic Transitional Cell C... more >>arcinoma Metastatic Urothelial Carcinoma Recurrent Bladder Carcinoma Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 Stage IV Bladder Urothelial Carcinoma AJCC v7 TSC1 Gene Mutation TSC2 Gene Mutation Collapse << | Phase 2 | Recruiting | - | United States, California ... more >> Los Angeles County-USC Medical Center Recruiting Los Angeles, California, United States, 90033 Contact: Site Public Contact 323-865-0451 Principal Investigator: David I. Quinn USC / Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Site Public Contact 323-865-0451 Principal Investigator: David I. Quinn Keck Medical Center of USC Pasadena Recruiting Pasadena, California, United States, 91105 Contact: Site Public Contact 323-865-0451 Principal Investigator: David I. Quinn University of California Davis Comprehensive Cancer Center Recruiting Sacramento, California, United States, 95817 Contact: Site Public Contact 916-734-3089 Principal Investigator: Primo N. Lara United States, Connecticut Smilow Cancer Center/Yale-New Haven Hospital Recruiting New Haven, Connecticut, United States, 06510 Contact: Site Public Contact 203-785-5702 canceranswers@yale.edu Principal Investigator: Joseph W. Kim Yale University Recruiting New Haven, Connecticut, United States, 06520 Contact: Site Public Contact 203-785-5702 canceranswers@yale.edu Principal Investigator: Joseph W. Kim United States, Illinois Northwestern University Recruiting Chicago, Illinois, United States, 60611 Contact: Site Public Contact 312-695-1301 cancer@northwestern.edu Principal Investigator: Alicia K. Morgans United States, Kansas University of Kansas Clinical Research Center Recruiting Fairway, Kansas, United States, 66205 Contact: Site Public Contact 913-945-7552 ctnursenav@kumc.edu Principal Investigator: Rahul A. Parikh United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Recruiting Baltimore, Maryland, United States, 21287 Contact: Site Public Contact 410-955-8804 jhcccro@jhmi.edu Principal Investigator: Noah M. Hahn United States, Massachusetts Massachusetts General Hospital Cancer Center Recruiting Boston, Massachusetts, United States, 02114 Contact: Site Public Contact 877-726-5130 Principal Investigator: David J. Kwiatkowski Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Site Public Contact 888-823-5923 ctsucontact@westat.com Principal Investigator: David J. Kwiatkowski Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: Site Public Contact 617-667-9925 Principal Investigator: David J. Kwiatkowski Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Site Public Contact 877-442-3324 Principal Investigator: David J. Kwiatkowski United States, Michigan University of Michigan Comprehensive Cancer Center Recruiting Ann Arbor, Michigan, United States, 48109 Contact: Site Public Contact 800-865-1125 Principal Investigator: Ajjai S. Alva United States, Nebraska Nebraska Medicine-Bellevue Recruiting Bellevue, Nebraska, United States, 68123 Contact: Site Public Contact 402-559-6941 unmcrsa@unmc.edu Principal Investigator: Benjamin A. Teply Nebraska Medicine-Village Pointe Recruiting Omaha, Nebraska, United States, 68118 Contact: Site Public Contact 402-559-5600 Principal Investigator: Benjamin A. Teply University of Nebraska Medical Center Recruiting Omaha, Nebraska, United States, 68198 Contact: Site Public Contact 402-559-6941 unmcrsa@unmc.edu Principal Investigator: Benjamin A. Teply United States, North Carolina UNC Lineberger Comprehensive Cancer Center Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Site Public Contact 877-668-0683 cancerclinicaltrials@med.unc.edu Principal Investigator: Matthew I. Milowsky United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Site Public Contact 412-647-8073 Principal Investigator: Leonard J. Appleman United States, Tennessee Vanderbilt University/Ingram Cancer Center Recruiting Nashville, Tennessee, United States, 37232 Contact: Site Public Contact 800-811-8480 Principal Investigator: Nancy B. Davis United States, Utah Huntsman Cancer Institute/University of Utah Recruiting Salt Lake City, Utah, United States, 84112 Contact: Site Public Contact 888-424-2100 cancerinfo@hci.utah.edu Principal Investigator: Sumati V. Gupta Collapse << |
NCT02327169 | Advanced Nonhematologic Malign... more >>ancies Collapse << | Phase 1 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 2114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 2115 Dana Farber Cancer Institute Boston, Massachusetts, United States, 2115 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 United States, Texas The University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 France Institut Bergonie Bordeaux cedex, Gironde, France, 33076 Institut Claudius Regaud-Oncopole Toulouse cedex 09, Haute Garonne, France, 31059 Institut Gustave Roussy Villejuif cedex, Val De Marne, France, 94805 Spain Hospital Universitari Vall d'Hebron Barcelona, Spain, 8035 START Madrid. Fundacion Jimenez Diaz Madrid, Spain, 28040 Hospital Clinico Universitario Virgen de la Victoria Malaga, Spain, 29010 United Kingdom Sarah Cannon Research Institure UK London, Greater London, United Kingdom, W1G 6AD The Chrisie Manchester, Greater Manchester, United Kingdom, M20 4BX Churchill Hospital Oxford, Oxfordshire, United Kingdom, OX3 7LJ Collapse << |
NCT02133183 | Glioblastoma ... more >>Gliosarcoma Collapse << | Phase 1 | Recruiting | - | United States, Alabama ... more >> University of Alabama at Birmingham Cancer Center Recruiting Birmingham, Alabama, United States, 35233 Contact: Site Public Contact 205-934-0220 tmyrick@uab.edu Principal Investigator: Louis B. Nabors United States, California UCLA / Jonsson Comprehensive Cancer Center Suspended Los Angeles, California, United States, 90095 UCSF Medical Center-Parnassus Suspended San Francisco, California, United States, 94143 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Recruiting Baltimore, Maryland, United States, 21287 Contact: Site Public Contact 410-955-8804 jhcccro@jhmi.edu Principal Investigator: Stuart A. Grossman United States, Massachusetts Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Site Public Contact 877-442-3324 Principal Investigator: Eudocia Q. Lee United States, Michigan Henry Ford Hospital Recruiting Detroit, Michigan, United States, 48202 Contact: Site Public Contact 313-916-1784 Principal Investigator: Tobias Walbert United States, North Carolina Wake Forest University Health Sciences Recruiting Winston-Salem, North Carolina, United States, 27157 Contact: Site Public Contact 336-713-6771 Principal Investigator: Glenn J. Lesser United States, Ohio Case Western Reserve University Suspended Cleveland, Ohio, United States, 44106 Cleveland Clinic Foundation Suspended Cleveland, Ohio, United States, 44195 United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Site Public Contact 412-647-8073 Principal Investigator: Frank S. Lieberman Collapse << |
NCT03648489 | Ovarian Cancer ... more >> Ovarian Neoplasms Ovarian Carcinosarcoma Ovarian Serous Adenocarcinoma Ovarian Endometrioid Adenocarcinoma Ovarian Clear Cell Adenocarcinoma Fallopian Tube Cancer Fallopian Tube Neoplasms Primary Peritoneal Carcinoma Primary Peritoneal Serous Adenocarcinoma Collapse << | Phase 2 | Not yet recruiting | March 2022 | United Kingdom ... more >> Imperial College Healthcare NHS Trust Not yet recruiting London, Greater London, United Kingdom, W12 0HS Contact: Senior Research Trials Coordinator Principal Investigator: Jonathan Krell Collapse << |
NCT02725268 | Endometrial Neoplasms | Phase 2 | Recruiting | September 30, 2019 | - |
NCT02049957 | Breast Cancer | Phase 2 | Completed | - | - |
NCT02756364 | Breast Neoplasms | Phase 2 | Active, not recruiting | May 28, 2019 | - |
NCT03154294 | Advanced Solid Tumor | Phase 1 | Recruiting | July 2021 | United States, South Dakota ... more >> Avera Cancer Institute Recruiting Sioux Falls, South Dakota, United States, 57105 Contact: Brian Leyland-Jones 605-322-6900 Brian.LeylandJones@avera.org Contact: Casey Williams 605-322-6900 Casey.Williams@Avera.org Collapse << |
NCT01899053 | Advanced Nonhematologic Malign... more >>ancies Collapse << | Phase 1 | Completed | - | United States, Massachusetts ... more >> Boston, Massachusetts, United States United States, Tennessee Nashville, Tennessee, United States United States, Texas San Antonio, Texas, United States Spain Barcelona, Spain United Kingdom Sutton, United Kingdom Collapse << |
NCT02724020 | Clear-cell Metastatic Renal Ce... more >>ll Carcinoma Collapse << | Phase 2 | Active, not recruiting | May 30, 2019 | - |
NCT02412722 | Non-Hematologic Malignancy | Phase 1 | Completed | - | United States, Arizona ... more >> Scottsdale, Arizona, United States United States, Florida Sarasota, Florida, United States United States, Oklahoma Oklahoma City, Oklahoma, United States United States, Tennessee Germantown, Tennessee, United States Nashville, Tennessee, United States Collapse << |
NCT02091531 | Metastatic Castration-Resistan... more >>t Prostate Cancer Collapse << | Phase 2 | Completed | - | United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
NCT01118689 | Relapsed Multiple Myeloma ... more >> Refractory Multiple Myeloma Waldenstrom Macroglobulinemia Collapse << | Phase 1 | Completed | - | United States, California ... more >> San Francisco, California, United States, 94143 United States, Colorado Denver, Colorado, United States, 80218 United States, Massachusetts Boston, Massachusetts, United States, 02115 United States, Missouri St. Louis, Missouri, United States, 63110 United States, New Jersey Hackensack, New Jersey, United States, 07601 United States, Tennessee Nashville, Tennessee, United States, 37203 Collapse << |
NCT01351350 | Advanced Solid Malignancies ... more >> Hematologic Malignancies Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Fort Myers, Florida, United States, 33905 United States, Oklahoma Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee Nashville, Tennessee, United States, 37203 Collapse << |
NCT02142803 | Adult Glioblastoma ... more >> Endometrial Clear Cell Adenocarcinoma Endometrial Serous Adenocarcinoma Ovarian Clear Cell Cystadenocarcinoma Ovarian Endometrioid Adenocarcinoma Ovarian Mucinous Cystadenocarcinoma Ovarian Serous Cystadenocarcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Recurrent Uterine Corpus Carcinoma Solid Neoplasm Stage IIIA Fallopian Tube Cancer AJCC v7 Stage IIIA Ovarian Cancer AJCC v6 and v7 Stage IIIA Primary Peritoneal Cancer AJCC v7 Stage IIIB Fallopian Tube Cancer AJCC v7 Stage IIIB Ovarian Cancer AJCC v6 and v7 Stage IIIB Primary Peritoneal Cancer AJCC v7 Stage IIIC Fallopian Tube Cancer AJCC v7 Stage IIIC Ovarian Cancer AJCC v6 and v7 Stage IIIC Primary Peritoneal Cancer AJCC v7 Stage IV Fallopian Tube Cancer AJCC v6 and v7 Stage IV Ovarian Cancer AJCC v6 and v7 Stage IV Primary Peritoneal Cancer AJCC v7 Collapse << | Phase 1 | Active, not recruiting | - | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Massachusetts General Hospital Charlestown, Massachusetts, United States, 02129 United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 Collapse << |
NCT02197572 | Advanced Solid Tumors | Phase 1 | Active, not recruiting | December 21, 2018 | United States, Florida ... more >> Sarasota, Florida, United States United States, Missouri Saint Louis, Missouri, United States United States, New York Bronx, New York, United States United States, Oklahoma Oklahoma City, Oklahoma, United States United States, Texas Dallas, Texas, United States Collapse << |
NCT02575339 | Hepatocellular Carcinoma ... more >> Liver Cancer HCC Collapse << | Phase 1 Phase 2 | Active, not recruiting | June 2020 | United States, Illinois ... more >> Northwestern University Feinberg School of Medicine Chicago, Illinois, United States, 60611 University of Illinois Cancer Center Chicago, Illinois, United States, 60612 United States, Indiana Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, North Carolina University of Noth Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27514 United States, Pennsylvania Penn State Cancer Institute Hershey, Pennsylvania, United States, 17033 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53705 Collapse << |
NCT03193853 | Triple Negative Breast Cancer | Phase 2 | Recruiting | June 9, 2022 | United States, Texas ... more >> Baylor University Medical Center Recruiting Dallas, Texas, United States, 75246 Contact: Amy Solis 214-820-8685 amy.solis@bswhealth.org Contact: Silviya Meletath, MD 214-820-4987 silviya.meletath@bswhealth.org Principal Investigator: Joyce O'Shaughnessy, MD Collapse << |
NCT02619669 | Breast Cancer | Phase 1 | Recruiting | December 2019 | United States, New Hampshire ... more >> Dartmouth Hitchcock Medical Center Recruiting Lebanon, New Hampshire, United States, 03756 Contact: Gary Schwartz, MD 800-639-6918 Cancer.Research.Nurse@Dartmouth.edu Sub-Investigator: Todd Miller, Ph.D Sub-Investigator: Mary Chamberlin, MD Sub-Investigator: Peter Kaufman, MD Sub-Investigator: Brad Arrick, MD Collapse << |
NCT02988986 | Estrogen Receptor Positive Bre... more >>ast Cancer Collapse << | Phase 2 | Active, not recruiting | August 2019 | United States, Texas ... more >> Houston Methodist Hospital Houston, Texas, United States, 77030 Houston Methodist Hospital Willowbrook Houston, Texas, United States, 77070 Houston Methodist Hospital Sugar Land Sugar Land, Texas, United States, 77479 Collapse << |
NCT03205891 | Malignant Neoplasms Stated as ... more >>Primary Lymphoid Haematopoietic Classical Hodgkin Lymphoma Anaplastic Large Cell Lymphoma CD30+ Peripheral T-cell Lymphoma Collapse << | Phase 1 | Withdrawn(Change in treatment ... more >>priorities for these disease types as well as staffing concerns.) Collapse << | March 2021 | - |
NCT03370302 | Advanced Nonhematological Neop... more >>lasms Collapse << | Phase 1 | Recruiting | October 8, 2019 | Japan ... more >> National Cancer Center Hospital East Recruiting Kashiwa-shi, Chiba-Ken, Japan, 277-8577 National Cancer Center Hospital Recruiting Chuo-ku, Tokyo-To, Japan, 104-0045 Korea, Republic of Asan Medical Center Not yet recruiting Seoul, Korea, Republic of, 05505 Taiwan National Taiwan-University Hospital Not yet recruiting Taipei, Taiwan, 100 Collapse << |
NCT02727777 | Lymphoma | Phase 1 Phase 2 | Terminated(Poor Accrual) | - | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT02719691 | Metastatic Breast Cancer ... more >> Solid Tumors Collapse << | Phase 1 | Recruiting | November 2018 | United States, Colorado ... more >> University of Colorado Cancer Center Recruiting Aurora, Colorado, United States, 80045 Contact: Matthew Lee 303-848-0630 matthew.lee@ucdenver.edu Principal Investigator: Jennifer Diamond, MD Collapse << |
NCT03430882 | Malignant Neoplasm of Breast ... more >> Malignant Neoplasms of Bone and Articular Cartilage Malignant Neoplasms of Digestive Organs Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System Malignant Neoplasms of Female Genital Organs Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites Malignant Neoplasms of Independent (Primary) Multiple Sites Malignant Neoplasms of Lip Oral Cavity and Pharynx Malignant Neoplasms of Male Genital Organs Malignant Neoplasms of Mesothelial and Soft Tissue Malignant Neoplasms of Respiratory and Intrathoracic Organs Malignant Neoplasms of Thyroid and Other Endocrine Glands Malignant Neoplasms of Urinary Tract Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic Collapse << | Phase 1 | Recruiting | March 2024 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact vsubbiah@mdanderson.org Collapse << |
NCT03745911 | Metastatic Urothelial Cancer | Phase 2 | Recruiting | November 2020 | Spain ... more >> Hospital General Universitario de Elche Recruiting Elche, Alicante, Spain, 03203 Contact: Federico J. Vázquez Mazón, MD/PhD fvazquezmd@gmail.com Principal Investigator: Federico J. Vázquez Mazón, MD/PhD Parc Taulí Hospital Universitario Recruiting Sabadell, Barcelona, Spain, 08208 Contact: Teresa Bonfilll, MD/PhD terebonfill@gmail.com Principal Investigator: Teresa Bonfill, MD/PhD Clínica Universitaria de Navarra Recruiting Pamplona, Navarra, Spain, 31008 Contact: José Luis Pérez Gracia, MD/PhD jlgracia@unav.es Principal Investigator: José Luis Pérez Gracia, MD/PhD Hospital del Mar Recruiting Barcelona, Spain, 08003 Contact: Alejo Rodríguez-Vida, MD/PhD arodriguezvida@hospitaldelmar.cat Principal Investigator: Alejo Rodríguez-Vida, MD/PhD Hospital de la Santa Creu i Sant Pau Recruiting Barcelona, Spain, 08041 Contact: José Pablo Maroto Rey, MD/PhD jmaroto@santpau.cat Principal Investigator: José Pablo Maroto Rey, MD/PhD Collapse << |
NCT02514824 | Merkel Cell Carcinoma | Phase 1 Phase 2 | Active, not recruiting | July 2020 | United States, Massachusetts ... more >> Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
NCT02812056 | Malignant Neoplasms of Digesti... more >>ve Organs Malignant Neoplasms of Female Genital Organs Malignant Neoplasms of Lip Oral Cavity and Pharynx Malignant Neoplasms of Male Genital Organs Collapse << | Phase 1 | Withdrawn | - | - |
NCT03017833 | Solid Tumor A... more >>dvanced Cancer Collapse << | Phase 1 | Recruiting | March 2023 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Clinical Research Operations CR_Study_Registration@mdanderson.org Collapse << |
NCT02244463 | Anaplastic Thyroid Cancer ... more >> Thyroid Cancer Collapse << | Phase 2 | Recruiting | January 2022 | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Contact: Jochen Lorch, MD 617-632-3090 jlorch@partners.org Principal Investigator: Jochen Lorch, MD Collapse << |
NCT01058707 | Advanced Solid Malignancies | Phase 1 | Active, not recruiting | October 31, 2018 | United States, Arizona ... more >> Scottsdale, Arizona, United States United States, California Los Angeles, California, United States United States, Florida Miami, Florida, United States Sarasota, Florida, United States United States, Indiana Indianapolis, Indiana, United States United States, Massachusetts Boston, Massachusetts, United States United States, Michigan Ann Arbor, Michigan, United States Detroit, Michigan, United States United States, New York Buffalo, New York, United States New York, New York, United States United States, Ohio Cleveland, Ohio, United States United States, Oklahoma Oklahoma City, Oklahoma, United States United States, Pennsylvania Philadelphia, Pennsylvania, United States United States, Tennessee Nashville, Tennessee, United States Spain Barcelona, Spain Valencia, Spain Collapse << |
NCT03097328 | Renal Cell Carcinoma | Phase 2 | Recruiting | August 25, 2024 | United States, Illinois ... more >> University of Chicago Medical Center Recruiting Chicago, Illinois, United States, 60637 Contact: Walter Stadler, MD wstadler@medicine.bsd.uchicago.edu Principal Investigator: Walter Stadler, MD United States, Massachusetts Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: David F. McDermott, MD 617-632-9250 Principal Investigator: David F McDermott, MD Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Lauren Harshman, MD 617-632-4524 LaurenC_Harshman@dfci.harvard.edu Principal Investigator: Lauren Harshman, MD Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02215 Contact: Dror Michaelson, MD 617-726-1594 Principal Investigator: Dror Michaelson, MD United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109 Contact: Ajjai Alva, MD Ajjai@med.umich.edu Principal Investigator: Ajjai Alva, MD Collapse << |
NCT02987959 | Soft-tissue Sarcoma | Phase 2 | Recruiting | September 2019 | United States, Pennsylvania ... more >> Fox Chase Cancer Center Recruiting Philadelphia, Pennsylvania, United States, 19111 Collapse << |
靶点 | Description | IC50 |
---|---|---|
mTOR | IC50:1nM |
联系我们
官方电话:400-920-2911
二维码
微信公众号 CSN官网