|皂素|CsnPharm

CAS No.: 8047-15-2

皂素，来源于满天星 Catalog No. CSN11895

Synonyms: Saponin;肥皂草素

Sapogenins glycosides are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effective for the treatment/prevention of venous insufficiency.

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生物活性

描述Sapogenins glycosides (saponins) are glycosidic ligands or non sugars, belonging to the saponins family of natural products. Most of these steroidal glycosides showed significant inhibitory activity against neutrophil respiratory burst stimulated by phorbol myristate acetate^[1]. Sapogenins are the aglycones, or non-saccharide, portions of the family of natural products known as saponins. They may non-competitively inhibit hyaluronidase and elastase activities. For Hedera helix L., the sapogenins only non-competitively inhibit hyaluronidase activity in a dose-dependent fashion, showing comparable IC50 values (hederagenin IC50 = 280.4 mM; oleanolic acid IC50 = 300.2 mM); both the saponins hederacoside C and alpha-hederin are very weak inhibitors. The same behaviour is observed for serine protease porcine pancreatic elastase: the glycosides are devoid of inhibitory action, while genins are potent competitive inhibitors (oleanolic acid IC50 = 5.1 mM; hederagenin IC50 = 40.6 mM)^[2].
参考文献

[1] Qi J, Hu ZF, Zhou YF, Hu YJ, Yu BY. Steroidal sapogenins and glycosides from the fibrous roots of Ophiopogon japonicus and Liriope spicata var. prolifera with anti-inflammatory activity. Chem Pharm Bull (Tokyo). 2015;63(3):187-94
[2] Facino RM, Carini M, Stefani R, Aldini G, Saibene L. Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. Arch Pharm (Weinheim). 1995 Oct;328(10):720-4

实验方案

计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	8047-15-2	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式		运输	蓝冰
分子量	N/A	别名	Saponin;肥皂草素

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皂素，来源于满天星 Catalog No. CSN11895

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