生物活性

• 描述Saroglitazar is a peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity withEC50values of 0.65 pM and 3 nM in HepG2 cells, respectively.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02265276	Fatty Liver	Phase 3	Unknown	September 2015	India ... more >> Command Hospital Recruiting Panchkula, Haryana, India, 134107 Contact: JBS Yadava    00911722867534    hariendo@gmail.com Collapse <<
  NCT03097107	Dyslipidemias	Phase 2	Suspended(Management decision ... more >>to suspend the study due to recruitment issues) Collapse <<	December 31, 2018	-
  NCT03061721	Non-Alcoholic Fatty Liver Dise... more >>ase Nonalcoholic Steatohepatitis Collapse <<	Phase 2	Recruiting	April 2019	United States, California ... more >> Precision Research Recruiting Chula Vista, California, United States, 91910 Contact: Research Site          Cedars-Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Research Site          Catalina Research Institute Recruiting Montclair, California, United States, 91763 Contact: Joe Calleros          California liver research institute Recruiting Pasadena, California, United States, 91105 Contact: Stephanie Tang          Precision Research Recruiting San Diego, California, United States, 92114 Contact: Research Site          Medical Associates Research Group Recruiting San Diego, California, United States, 92123 Contact: Tina Delrosa          United States, Florida University of Florida Recruiting Gainesville, Florida, United States, 32601 Contact: Research Site          Schiff Center for Liver Diseases/University of Miami Recruiting Miami, Florida, United States, 33136 Contact: Diane Sabogal          Avail Clinical Research Recruiting Orange City, Florida, United States, 32763 Contact: Samantha Watts          United States, Indiana Indiana University Recruiting Indianapolis, Indiana, United States, 46290 Contact: Research Site          United States, Maryland Mercy Medical Center Recruiting Baltimore, Maryland, United States, 21201 Contact: Research Site          United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109-5362 Contact: Elizabeth Wu          Henry Ford Hospital Recruiting Detroit, Michigan, United States, 48202 Contact: Research Site          United States, North Carolina Wake Internal Medicine Withdrawn Raleigh, North Carolina, United States, 27612 United States, Ohio Awasty Research Network, LLC Recruiting Marion, Ohio, United States, 43302 Contact: Elisia Baldwin          United States, Pennsylvania Einstein Medical Center Recruiting Philadelphia, Pennsylvania, United States, 19141 Contact: Stacey J Carmody          United States, Tennessee Gastro One Recruiting Germantown, Tennessee, United States, 38138 Contact: Laurie Martin          AIG Research Recruiting Hermitage, Tennessee, United States, 37076 Contact: Research Site          United States, Texas Liver Consultants Recruiting Dallas, Texas, United States, 75246 Contact: Research Site          The Liver Institute Recruiting San Antonio, Texas, United States, 78215 Contact: Research Site          United States, Washington Swedish Medical Center Recruiting Seattle, Washington, United States, 89104 Contact: Research Site Collapse <<

• 更多
• 参考文献

• [1] Patel MR, Kansagra KA, et al. Effect of Food on the Pharmacokinetics of Saroglitazar Magnesium, a Novel Dual PPARαγ Agonist, in Healthy Adult Subjects. Clin Drug Investig. 2017 Oct 11.

  [2] Jain MR, Giri SR, et al. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models. Pharmacol Res Perspect. 2015 Jun;3(3):e00136.