|N-(4-((6-氯吡啶-3-基)甲氧基)-3-甲氧基苄基)-2-(3,4-二甲氧基苯基)乙烷-1-胺盐酸盐|CsnPharm

CAS No.: 1052532-15-6

SBE13 HCl/SBE 13盐酸盐 Catalog No. CSN16924

Synonyms: SBE 13 (hydrochloride);SBE-13 HCl

SBE13 HCl is a potent and selective PLK1 inhibitor with IC50 of 0.2 nM while 875 nM and 66 μM for PLK3 and PLK2. SBE 13 could also induce cell cycle arrest, reduce cell proliferation with EC50 of 5-60 µM, and induce apoptosis in a broad range of human cancer cell lines.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 PLK1

IC50:0.2nM
描述Human polo-like kinase 1 (Plk1), a key regulator of mitosis, is over-expressed in various human tumors. It is a negative prognostic factor for cancer patients and a measure for the aggressiveness of a tumor. SBE13 (10 and 100 μM) reduces pRb staining in primary cells, and this indicates a G0/G1 arrest. After treatment with SBE13 the G₁//S checkpoint was intact, indicated by reduced pRb, resulting in slower cell cycle progression but overall cell proliferation was not significantly impaired^[3].SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM. SBE13 significantly reduce cell proliferation and induce apoptosis in HeLa cells, with an EC50 of 18 μM^[4]. SBE13 (66 and 100 μM) increases levels of cyclin B1, phospho histone H3, Wee1, Emi1 and securin, and results in cleavage of Cdc27 in HeLa cells. Decreased cell proliferation, delayed progression through the cell cycle in lower SBE13 concentrations, a G(2)/M arrest using higher SBE13 concentrations followed by apoptosis, and abnormal mitotic figures^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0860 mL
- 10.4298 mL
- 20.8596 mL
- 5 mM
- 0.4172 mL
- 2.0860 mL
- 4.1719 mL
- 10 mM
- 0.2086 mL
- 1.0430 mL
- 2.0860 mL

技术信息

CAS号

1052532-15-6

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H28Cl2N2O4

运输

蓝冰

分子量

479.40

别名

SBE 13 (hydrochloride);SBE-13 HCl

溶解度

DMSO	95.0 mg/mL (198.2 mM)
Water	Insoluble
Ethanol	Insoluble

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SBE13 HCl/SBE 13盐酸盐 Catalog No. CSN16924

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