|(6R,7S)-1,2,3,13-四甲氧基-6,7-二甲基-5,6,7,8-四氢苯并[3',4']环辛并[1',2':4,5]苯并[1,2-d] [1,3]二氧杂环戊烯|CsnPharm

CAS No.: 61281-37-6

Schizandrin B/五味子乙素 Catalog No. CSN16432

Synonyms: γ-Schisandrin;Wuweizisu B;SCH B

Schisandrin B is a naturally occuring anti-inflammatory and antioxidant agent which can inhibit ROS production in microglia.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Schisandrin B is a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart. SB inhibited mitogen-induced proliferation and cytokine secretion by lymphocytes. SB also significantly inhibited mitogen-induced upregulation of T cell costimulatory molecules and activation markers. Similar anti-inflammatory effects of SB on lymphocyte proliferation and cytokine secretion were also observed in vivo^[3]. Sch B can protect neuronal cells against oxidative challenge, presumably by functioning as a hormetic agent to sustain cellular redox homeostasis and mitoenergetic capacity in neuronal cells^[4]. Sch B may exert neuroprotective activity by attenuating the microglial-mediated neuroinflammatory response by inhibiting the TLR4-dependent MyD88/IKK/NF-κB signaling pathway^[5]. Sch B significantly suppressed the spontaneous lung and bone metastasis of 4T1 cells inoculated s.c. without significant effect on primary tumor growth and significantly extended the survival time of these mice^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02185638	Obesity	Not Applicable	Completed	-	Denmark ... more >> Department Of Human Nutrition, Faculty of Science, University of Copenhagen Frederiksberg, Denmark, 1958 Collapse <<
NCT02250027	Acute Bronchitis ... more >> Acute Exacerbations of Chronic Bronchitis Collapse <<	Phase 2	Completed	-	Korea, Republic of ... more >> Kyung Hee University Hospital Seoul, Korea, Republic of, 130-872 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4971 mL
- 12.4855 mL
- 24.9710 mL
- 5 mM
- 0.4994 mL
- 2.4971 mL
- 4.9942 mL
- 10 mM
- 0.2497 mL
- 1.2485 mL
- 2.4971 mL

技术信息

CAS号

61281-37-6

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H28O6

运输

蓝冰

分子量

400.46

别名

γ-Schisandrin;Wuweizisu B;SCH B;gamma-Schisandrin;Schisandrin BSchisandrin B;五味子乙素

溶解度

DMSO	80.0 mg/mL (199.8 mM)
Water	Insoluble
Ethanol	10.0 mg/mL (25.0 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Schizandrin B/五味子乙素 Catalog No. CSN16432

靶点选择性

请登录您的专属账户

确认信息