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CAS No.: 498-45-3

Scopine/东莨菪醇 Catalog No. CSN12682

Synonyms: 6,7-Epoxytropine;Scopanol

Scopine is a naturally occuring α1-adrenergic receptor agonist which is the metabolite of anisodine, used in the treatment of acute circulatory shock.

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技术信息

生物活性

描述Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and is used in the treatment of acute circulatory shock. Chlorambucil (CHL), an alkylating agent, as the model therapeutic agent, and used scopine as a novel brain-targeting moiety. The tissue distribution study after i.v. injection revealed that the AUC0-t and Cmax of CHLS in the brain were 14.25- and 12.20-fold of CHL, respectively. Specifically, CHLS (Chlorambucil-Scopine) accumulated in bEnd.3 and C6 cells in an energy-dependent manner. In C6 cells, superior anti-glioma activity with a significantly decreased IC50 of 65.42 nM/mL was observed for CHLS compared to CHL (IC50 > 400 nM/mL). Scopine is a potential brain-targeting moiety for enhancing the brain uptake efficiency of CHL (chlorambucil)^[3].
参考文献

[1] ecija P, Vallejo-Lopez M, et al. Scopine Isolated in the Gas Phase. Chemphyschem. 2016 Oct 5;17(19):3030-3034.
[2] Wang X, Li J, et al. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug Chem. 2014 Nov 19;25(11):2046-54.
[3] Wang X, Li J, Xu C, et al. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug Chem. 2014;25(11):2046-2054

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.4435 mL
- 32.2177 mL
- 64.4354 mL
- 5 mM
- 1.2887 mL
- 6.4435 mL
- 12.8871 mL
- 10 mM
- 0.6444 mL
- 3.2218 mL
- 6.4435 mL

技术信息

CAS号

498-45-3

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H13NO2

运输

蓝冰

分子量

155.19

别名

6,7-Epoxytropine;Scopanol

溶解度

DMSO	500.0 mg/mL (3221.8 mM)
Water	500.0 mg/mL (3221.8 mM)

动物实验配方

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