|2-氨基-2-(羟甲基)丙烷-1,3-二醇 (3-((4-((2-氨基-3-氯吡啶-4-基)氧基)-3-氟苯基)氨基甲酰基)-5-(4-氟苯基)-4-氧代吡啶-1(4H)-基)甲基磷酸盐|CsnPharm

CAS No.: 1174161-86-4

SCR-1481B1 Catalog No. CSN17517

Synonyms: c-Met inhibitor 2;BMS-817378;Metatinib anhydrous

SCR-1481B1 is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Met, also referred to as hepatocyte growth factor receptor (HGFR), is expressed predominantly in epithelial cells. Overexpression of hepatocyte growth factor and activation of Met has been associated with the onset and progression in a number of different tumor types as well as in the promotion of metastatic disease. SCR-1481B1 is a potent inhibitor of Met that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor^[2].
参考文献

[1] WO2009094417A1
[2] Robert M. Borzilleri, et al. 4-pyridinone compounds and their use for cancer. WO/2009094417/A1

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4286 mL
- 7.1431 mL
- 14.2861 mL
- 5 mM
- 0.2857 mL
- 1.4286 mL
- 2.8572 mL
- 10 mM
- 0.1429 mL
- 0.7143 mL
- 1.4286 mL

技术信息

CAS号

1174161-86-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C28H29ClF2N5O10P

运输

蓝冰

分子量

699.98

别名

c-Met inhibitor 2;BMS-817378;Metatinib anhydrous

溶解度

DMSO	95.0 mg/mL (135.7 mM)
Water	4.67 mg/mL (6.7 mM)

动物实验配方

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