|6-(1,3-二氧代-1H-苯并[de]异喹啉-2(3H)-基)-N-羟基己酰胺|CsnPharm

CAS No.: 287383-59-9

Scriptaid Catalog No. CSN13123

Synonyms: Scriptide;GCK1026

Scriptaid is an inhibitor of HDAC with greater effect on acetylated H4.

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技术信息

生物活性

描述Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research. Scriptaid (1 µg/mL) treatment inhibits cell growth in breast cancer cell lines, results in increased accumulation of both acetyl H3 and acetyl H4 proteins in MDA-MB-231, MDA-MB-435, and Hs578t cells. Scriptaid also inhibits cell growth of MDA-MB-231, MDA-MB-435, and Hs578t cell lines, with IC50s of 0.5-1.0 µg/mL. Scriptaid (0.1-1.0 µg/mL) induces ER and PR mRNA expression in a dose dependent manner; when it is combined with AZA(5-aza-2'-deoxycytidine), they enhance ER expression and induce a functional ER protein (estrogen receptor alpha)^[3]. Scriptaid and SAHA (suberoylanilide hydroxamic acid) preferentially inhibit the Class I histone deacetylases, hdac1, 2, and 3. Scriptaid is a potent anti-T. gondii compound with low cytotoxicity, and the IC50 is 39 nM. Scriptaid has atypical effects in T. gondiiinfected HS68 cells^[4]. Scriptaid inhibited the growth of HeLa cells with IC50 of 2μM at 48h in a dose-dependent manner^[5]. Treatment with 500nM scriptaid caused a significant increase in the acetylation of H3K9, H3K14, and H4K5. cEFs treated with 500nM. Scriptaid showed significantly decreased Gcn5, Hat1, Hdac6, and Bcl2 and increased Oct4 and Sox2 expression levels. Scriptaid affected the reprogramming of canine donor and cloned embryos, as well as early embryo development in canine-porcine iSCNT, by regulating reprogramming and apoptotic genes^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0642 mL
- 15.3211 mL
- 30.6423 mL
- 5 mM
- 0.6128 mL
- 3.0642 mL
- 6.1285 mL
- 10 mM
- 0.3064 mL
- 1.5321 mL
- 3.0642 mL

技术信息

CAS号

287383-59-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H18N2O4

运输

蓝冰

分子量

326.35

别名

Scriptide;GCK1026

溶解度

DMSO	310.0 mg/mL (949.9 mM)
Water	insoluble

动物实验配方

2% DMSO+30% PEG 300+2% Tween 80+water

7 mg/mL

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