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CAS No.: 3366-95-8

Secnidazole/塞克硝唑 Catalog No. CSN11909

Synonyms: RP-14539;PM-185184;SYM-1219

Secnidazole is a nitroimidazole anti-infective drug.

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技术信息

生物活性

描述Secnidazole, a 5-nitroimidazole with a longer half-life, is structurally related to metronidazole and tinidazole. For treatment of bacterial vaginosis (BV), secnidazole is a suitable single-dose oral drug having a longer serum half-life than metronidazole. The MIC90 (μg/mL) for secnidazole was similar to metronidazole and tinidazole for Anaerococcus tetradius (secnidazole: MIC90 2; metronidazole: MIC90 2; tinidazole: MIC90 4), Atopobium vaginae (32; >128; 128), Bacteroides species (2; 2; 2), Finegoldia magna (2; 2; 4), Gardnerella vaginalis (128; 64; 32), Mageeibacillus indolicus (2; 2; 2), Megasphaera-like bacteria (0.5; 0.25; 0.5), Mobiluncus curtisii (128; >128; >128) and Mobiluncus mulieris (>128; >128; >128), Peptoniphilus lacrimalis (4; 4; 4) and Peptoniphilus harei (2; 2; 4), Porphyromonas species (0.25; 0.5; 0.25), Prevotella bivia (8; 8; 8), Prevotella amnii (2; 1; 2) and Prevotella timonensis (2; 2; 2). The MIC90 for all lactobacilli tested was >128 μg/mL for secnidazole, metronidazole and tinidazole^[3]. The clinical cure rate, microbiological effect and the therapeutic cure rate of 2 g secnidazole was significantly more than that of 1 g secnidazole^[4]. Secnidazole is an effective and easily administered drug for the treatment of clinical canine giardiosis. Giardiosis resolved in all 14 patients in Group A within 13 days following a single oral dose of secnidazole (30 mg/kg). For the young puppies in Group B, giardiosis was reduced by 90% (9/10) within 22 days following two consecutive doses of secnidazole (30 mg/kg; 2 weeks apart)^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01019083	Cholera Typho... more >>id Collapse <<	Phase 1 Phase 2	Completed	-	Bangladesh ... more >> Firdausi Qadri Dhaka, Bangladesh, 1212 Collapse <<
NCT00607074	Giardiasis	Not Applicable	Completed	-	Bangladesh ... more >> National Institute of Preventive and Social Medicine Mohakhali, Dhaka, Bangladesh, 1212 Collapse <<
NCT01733966	Diverticular Sigmoïditis	Phase 3	Terminated(difficulties to rec... more >>ruit patients who suffer from this pathology) Collapse <<	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.4001 mL
- 27.0007 mL
- 54.0014 mL
- 5 mM
- 1.0800 mL
- 5.4001 mL
- 10.8003 mL
- 10 mM
- 0.5400 mL
- 2.7001 mL
- 5.4001 mL

技术信息

CAS号

3366-95-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H11N3O3

运输

蓝冰

分子量

185.18

别名

RP-14539;PM-185184;SYM-1219;trade name: Flagentyl;Secnol;Deprozol;Sabima;Sindose;Secnil;塞克硝唑

溶解度

DMSO	35.0 mg/mL (189.0 mM)
Water	35.0 mg/mL (189.0 mM)
Ethanol	35.0 mg/mL (189.0 mM)

动物实验配方

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