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CAS No.: 163253-35-8

Sitafloxacin hydrate/西他沙星水合物 Catalog No. CSN17975

Synonyms: DU6859a hydrate;DU-6859;DU-6859A

Sitafloxacin Hydrate is a fluoroquinolone antibiotic with promising effect on the treatment of Buruli ulcer.

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技术信息

生物活性

描述Sitafloxacin hydrate, a new-generation, broad-spectrum oral fluoroquinolone, was recently approved for the treatment of respiratory and urinary tract infections. Sitafloxacin is active against methicillin-resistant staphylococci, Streptococcus pneumoniae and other streptococci. Sitafloxacin has also demonstrated activity against clinical isolates of Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa with some activity against quinolone-resistant strains and Acinetobacter baumannii^[3]. The sitafloxacin MIC ranged from 0.03 to 0.06mg/mL against C. pneumoniae(7 isolates) and was 0.03mg/mL against C. trachomatis(7 isolates). Sitafloxacin showed activity in various animal models of infection, including a rat model of uterine endometritis associated with E. coli and B. fragilis, mouse models of penicillin-sensitive or -resistant S. pneumoniae lung infection, a mouse model of H. influenzae lung infection, and rat models of complicated urinary tract infection associated with P. aeruginosa^[4]. In a published phase II randomized, open-label, multicenter study of patients hospitalized with pneumonia, sitafloxacin (400 mg once daily) was comparable to imipenem/cilastatin (500 mg three times a day)^[3].
参考文献

[1] Keating GM. Sitafloxacin: in bacterial infections. Drugs. 2011 Apr 16;71(6):731-44.
[2] Anderson DL. Sitafloxacin hydrate for bacterial infections. Drugs Today (Barc). 2008 Jul;44(7):489-501.
[3] Anderson DL. Sitafloxacin hydrate for bacterial infections. Drugs Today (Barc). 2008;44(7):489‐501
[4] Keating GM. Sitafloxacin: in bacterial infections. Drugs. 2011;71(6):731‐744

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1446 mL
- 5.7230 mL
- 11.4459 mL
- 5 mM
- 0.2289 mL
- 1.1446 mL
- 2.2892 mL
- 10 mM
- 0.1145 mL
- 0.5723 mL
- 1.1446 mL

技术信息

CAS号

163253-35-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C38H42Cl2F4N6O9

运输

蓝冰

分子量

873.67

别名

DU6859a hydrate;DU-6859;DU-6859A;Sitafloxacin;Sitafloxacin anhydrous;Trade name: Gracevit;西他沙星水合物

溶解度

DMSO	4.0 mg/mL (4.6 mM) warming
Water	Insoluble
Ethanol	Insoluble

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