|3-巯基吡啶-2-甲酸盐酸盐|CsnPharm

CAS No.: 320386-54-7

SKF-34288 HCl/3-巯基吡啶-2-甲酸盐酸盐 Catalog No. CSN27710

Synonyms: 3-Mercaptopicolinic acid hydrochloride;3-Mercaptopicolinic acid HCl;3-Mercaptopicolinic Acid (hydrochloride)

SKF-34288 HCl is a PEPCK inhibitor which could inhibit glucose synthesis through inhibition of PEPCK in the gluconeogenesis pathway.

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技术信息

生物活性

描述PEPCK (phosphoenolpyruvate carboxykinase) has a key role in highly gluconeogenic tissues such as liver and kidney, converting lactateand other precursors to glucose and releasing the sugar into the bloodstream. SKF-34288 HCl is a PEPCK inhibitor which is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway^[1]. Supplying MPA decreased xylem recycling in the leaf as there was an increase in the amount of amino acids, 2cm from the base and at the tip. Feeding MPA increased the volume of the xylem exudate and guttation fluid in the control leaves, except at the base. Feeding MPA clearly inhibited Asn metabolism and resulted in an increase in amino acids and amides in the xylem^[2].
作用机制Binding of SKF-34288 to the allosteric pocket stabilizes an altered conformation of the nucleotide-binding site that in turn reduces the affinity of the enzyme for the nucleotide^[1].
参考文献

[1] Balan MD, et al. Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry. 2015 Sep 29;54(38):5878-87
[2] Bailey KJ, et al. Nitrogen recycling from the xylem in rice leaves: dependence upon metabolism and associated changes in xylem hydraulics. J Exp Bot. 2016 Apr;67(9):2901-11

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2182 mL
- 26.0912 mL
- 52.1825 mL
- 5 mM
- 1.0436 mL
- 5.2182 mL
- 10.4365 mL
- 10 mM
- 0.5218 mL
- 2.6091 mL
- 5.2182 mL

技术信息

CAS号

320386-54-7

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H6ClNO2S

运输

蓝冰

分子量

191.64

别名

3-Mercaptopicolinic acid hydrochloride;3-Mercaptopicolinic acid HCl;3-Mercaptopicolinic Acid (hydrochloride);SKF 34288;3-MPA hydrochloride

溶解度

Water

5.0 mg/mL (26.1 mM) warming

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SKF-34288 HCl/3-巯基吡啶-2-甲酸盐酸盐 Catalog No. CSN27710

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