CAS No.: 1259484-97-3
SKI-178 Catalog No. CSN20618
Synonyms: Ski-178
SKI-178 is an in vivo active non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM), which induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn
纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Hengst JA, Dick TE, et al. SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Transl Med. 2017 Jul-Aug;3(4):109-121.
- [2] Hengst JA, Wang X, et al. Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7498-502.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1259484-97-3 | 储存条件 |
|
|
| 分子式 | C21H22N4O4 | 运输 | 蓝冰 | |
| 分子量 | 394.42 | 别名 | Ski-178 |
