生物活性

• 描述Sobetirome is a member of a class of compounds known as selective thyromimetics.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01787578	X-Linked Adrenoleukodystrophy ... more >> Adrenomyeloneuropathy Collapse <<	Phase 1	Withdrawn(revisions to origina... more >>l study protocol underway) Collapse <<	-	United States, Oregon ... more >> Oregon Health & Science University Portland, Oregon, United States, 97239 Collapse <<
  NCT03196765	X-Linked Adrenoleukodystrophy	Phase 1 Phase 2	Recruiting	December 1, 2020	Argentina ... more >> Hospital Austral Not yet recruiting Buenos Aires, Argentina Hospital General de ninos Pedro de Elizalde Not yet recruiting Buenos Aires, Argentina Australia, Victoria Monash Health Recruiting Clayton, Victoria, Australia, 3168 Contact: Michael Fahey, M.D.       michael.fahey@monash.edu    Chile Hospital Clínico San Borja Arriarán Not yet recruiting Santiago, Chile Hospital Dr. Luis Calvo Mackenna Recruiting Santiago, Chile Contact: Constanza Ruiz Berger    56972174121    cruizberger@gmail.com    Contact: Patricia Acuna Rosales    56982482811    patricia.ar78@gmail.com    Principal Investigator: Ricardo Erazo Torricelli, MD          Colombia Fundacion Cardioinfantil Not yet recruiting Bogotá, Colombia France Hôpital Bicêtre - Paris Sud Not yet recruiting Paris, France Russian Federation Endocrinology Research Center Not yet recruiting Moscow, Russian Federation Moscow Morozov`s Children Clinical Hospital Not yet recruiting Moscow, Russian Federation Saint Petersburg State Pediatric Medical University Not yet recruiting Saint Petersburg, Russian Federation Ukraine National Children's Specialized Hospital 'OKHMATDET' Not yet recruiting Kiev, Ukraine United Kingdom Great Ormond Street Hospital for Children Recruiting London, United Kingdom Contact: Christopher Jackson    +44 (0)2077626897    Christopher.Jackson@gosh.nhs.uk    Principal Investigator: James Davison, MD          Manchester Children's Hospital Recruiting Manchester, United Kingdom Contact: Margretha Amegadzie       Margretha.Amegadzie@mft.nhs.uk    Principal Investigator: Andrew Morris, MD Collapse <<

• 参考文献

• [1] Gierach I, Li J, et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53.

  [2] Johansson L, Rudling M, et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302.