CAS No.: 149606-27-9
Soblidotin Catalog No. CSN18933
Synonyms: Auristatin PE;TZT-1027
Auristatin PE is a synthetic Dolastatin 10 derivative and inhibitor oftubulinpolymerization.
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靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00064220 Sarcoma Phase 2 Completed - United States, Alabama ... more >> University of Alabama at Birmingham Comprehensive Cancer Center Birmingham, Alabama, United States, 35294-3300 United States, Indiana Indiana University Cancer Center Indianapolis, Indiana, United States, 46202-5289 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Herbert Irving Comprehensive Cancer Center at Columbia University New York, New York, United States, 10032 United States, Texas University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 Puerto Rico Veterans Affairs Medical Center - San Juan San Juan, Puerto Rico, 00927-5800 Collapse << NCT00072228 Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << Phase 1 Withdrawn - United States, New Mexico ... more >> University of New Mexico Cancer Research and Treatment Center Albuquerque, New Mexico, United States, 87131-5636 United States, New York Herbert Irving Comprehensive Cancer Center at Columbia University New York, New York, United States, 10032 Collapse << NCT00061854 Lung Cancer Phase 2 Completed - United States, Connecticut ... more >> Medical Oncology and Hematology, P.C. Waterbury, Connecticut, United States, 06708 United States, Michigan Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201-1379 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Collapse << - 参考文献
- [1] Fanale D, Bronte G, et al. Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option? Anal Cell Pathol(Amst). 2015;2015:690916.
- [2] Watanabe K, Tanimura S, et al. Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubule-destabilizing agents in human tumor xenograft models. Clin Cancer Res. 2010 Feb 15;16(4):1170-8.
实验方案
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技术信息
| CAS号 | 149606-27-9 | 储存条件 |
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| 分子式 | C39H67N5O6 | 运输 | 蓝冰 | |
| 分子量 | 701.98 | 别名 | Auristatin PE;TZT-1027 |
