|(3S,4R,5R)-6-((氢膦酸)氧基)-3,4,5-三羟基-2-氧代己基磷酸三钠盐 x水合物|CsnPharm

CAS No.: 41012-14-0

Sodium (3S,4R,5R)-6-((hydrogenphosphonato)oxy)-3,4,5-trihydroxy-2-oxohexyl phosphate xhydrate Catalog No. CSN24845

Synonyms: D-Fructose 1,6-bisphosphate trisodium salt xhydrate

D-Fructose-1,6-diphosphate trisodium salt octahydrate is a salt form of D-Fructose-1,6-diphosphate. D-Fructose-1,6-bisphosphate is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It is an allosteric activator of enzymes such as pyruvate kinase.

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生物活性

描述D-Fructose-1,6-diphosphate trisodium salt octahydrate (FBP trisodium salt octahydrate) is a common metabolic carbohydrate. It is a precursor compound of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. In the thread-drawing group, thrombus was obvious, and the endovascular elastic membrane was injured seriously compared with the ligating group. After being treated with aspirin and clopidogrel, most arterial thrombus was softened, dissolved and absorbed. Compared with that in the modified thread-drawing group,wet and dry weight of thrombus increased,and the level of D-Dimer, FDP (D-Fructose-1,6-diphosphate trisodium salt octahydrate) and TF (tissue factor) also increased in the modified thread-drawing group. After being treated by aspirin and/or clopidogrel, the wet and dry weight of thrombus and the level of D-Dimer, FDP and TF decreased compared with the control. Aspirin plus clopidogral could obviously reduce the wet and dry weight of thrombus, and reduce the level of D-Dimer and FDP^[2]. D-Fructose 1,6-bisphosphate trisodium salt octahydrate is also a substrate of Aldolase, liver FBPaseand and muscle FBPase. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1, 6-bisphosphatase(s). D-Fructose-1,6-bisphosphate is studied as a neuroprotective agent in brain injury^[3].
参考文献

[1] Nghiem NP, Cofer TM. Effect of a nonmetabolizable analog of fructose-1,6-bisphosphate on glycolysis and ethanol production in strains of Saccharomyces cerevisiae and Escherichia coli. Appl Biochem Biotechnol. 2007 May-Jun;141(2-3):335-47. doi: 10.1007/BF02729071. PMID: 18025560.
[2] Wang DS, Chen FP, He SL, Huang XL, Fu B, Xiao CJ, Tang FQ. [Establishment and evaluation of a rabbit model of arterial thrombosis by collagen encapsulated thread-drawing]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;33(11):993-8. Chinese
[3] Song X, Wu B, Takata T, Wang X, Oizumi XS, Akisaki T, Yokono K, Sakurai T. Neuroprotective effect of D-fructose-1,6-bisphosphate against beta-amyloid induced neurotoxicity in rat hippocampal organotypic slice culture: involvement of PLC and MEK/ERK signaling pathways. Kobe J Med Sci. 2005;51(5-6):73-83

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3581 mL
- 11.7903 mL
- 23.5807 mL
- 5 mM
- 0.4716 mL
- 2.3581 mL
- 4.7161 mL
- 10 mM
- 0.2358 mL
- 1.1790 mL
- 2.3581 mL

技术信息

CAS号	41012-14-0	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C6H13Na3O13P2	运输	蓝冰
分子量	424.08	别名	D-Fructose 1,6-bisphosphate trisodium salt xhydrate

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Sodium (3S,4R,5R)-6-((hydrogenphosphonato)oxy)-3,4,5-trihydroxy-2-oxohexyl phosphate xhydrate Catalog No. CSN24845

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