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CAS No.: 142-47-2

谷氨酸单钠盐 Catalog No. CSN11296

Synonyms: Monosodium glutamate|MSG;Monosodium Glutamate;MSG

L-Glutamic Acid Monosodium is an excitatory amino acid neurotransmitter as an agonist at GluR and NMDA receptor.

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技术信息

生物活性

描述L-Glutamic acid monosodium acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). Mice at postnatal day 9 were challenged with a toxic dose of monosodium glutamate (MSG, 3g/kg), which caused the death of >70% of Brn-3a+ RGCs(retinal ganglion cell). Systemic administration of the mGlu1 receptor negative allosteric modulator (NAM), JNJ16259685 (2.5mg/kg, s.c.), was largely protective against MSG-induced RGC death^[3]. Phenylglutamic acid suppressed aggression in the test for provoked unmotivated aggression, while L-glutamic acid enhanced it^[4]. L-GA (L-glutamic acid) increased locomotor activity, muscle coordination, and cerebral blood flow in ischemic mice at 72 h after ischemic insult. L-GA reduced glutamate levels in the cortex, striatum, and hippocampus at 72 h, whereas GABA levels were elevated in all three brain regions studied. Further, L-GA elevated glutathione levels and attenuated nitric oxide levels, but failed to restore ATP levels 72 h after ischemia-reperfusion. A slow infusion of a low dose of L-GA could be beneficial in controlling excitotoxicity-induced neurodegeneration following ischemia^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02255812	Exploratory Behavior	Not Applicable	Completed	-	Switzerland ... more >> University Hospital Basel, Switzerland, CH-4031 Collapse <<
NCT03140930	Obesity	Not Applicable	Completed	-	Netherlands ... more >> Maastricht University Medical Center Maastricht, Limburg, Netherlands, 6229HX Collapse <<
NCT00112112	Cancer	Phase 1	Completed	-	United States, New York ... more >> University of Rochester School of Medicine & Dentistry Rochester, New York, United States, 14642 Stony Brook University Medical Center Stony Brook, New York, United States, 11794 United States, Tennessee St. Jude's Children's Research Hospital Memphis, Tennessee, United States, 38105 Vanderbilt University Nashville, Tennessee, United States, 37232 United States, Washington Children's Hospital Regional Medical Center Seattle, Washington, United States, 98105 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.9133 mL
- 29.5664 mL
- 59.1327 mL
- 5 mM
- 1.1827 mL
- 5.9133 mL
- 11.8265 mL
- 10 mM
- 0.5913 mL
- 2.9566 mL
- 5.9133 mL

技术信息

CAS号

142-47-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H8NNaO4

运输

蓝冰

分子量

169.11

别名

Monosodium glutamate|MSG;Monosodium Glutamate;MSG;Sodium glutamate;谷氨酸单钠盐;L-谷氨酸一钠

溶解度

DMSO	insoluble
Water	350.0 mg/mL (2069.6 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02255812	Exploratory Behavior	Not Applicable	Completed	-	Switzerland ... more >> University Hospital Basel, Switzerland, CH-4031 Collapse <<
NCT03140930	Obesity	Not Applicable	Completed	-	Netherlands ... more >> Maastricht University Medical Center Maastricht, Limburg, Netherlands, 6229HX Collapse <<
NCT00112112	Cancer	Phase 1	Completed	-	United States, New York ... more >> University of Rochester School of Medicine & Dentistry Rochester, New York, United States, 14642 Stony Brook University Medical Center Stony Brook, New York, United States, 11794 United States, Tennessee St. Jude's Children's Research Hospital Memphis, Tennessee, United States, 38105 Vanderbilt University Nashville, Tennessee, United States, 37232 United States, Washington Children's Hospital Regional Medical Center Seattle, Washington, United States, 98105 Collapse <<
NCT03010930	Umami Taste Perception	Not Applicable	Completed	-	-
NCT00112112	-	-	Completed	-	-
NCT03342482	Gulf War Syndrome	Not Applicable	Recruiting	August 31, 2020	United States, District of Col... more >>umbia American University Recruiting Washington, District of Columbia, United States, 20016 Contact: Meissa M Jones, MS 202-885-3810 mjones@american.edu Principal Investigator: Kathleen F Holton, PhD Collapse <<
NCT02902198	Obesity	Not Applicable	Recruiting	July 2019	Switzerland ... more >> University Hopital Basel Recruiting Basel, Switzerland Contact: Bettina Wölnerhanssen, Dr bettina.woelnerhanssen@usb.ch Collapse <<
NCT00829218	Irritable Bowel Syndrome ... more >> Fibromyalgia Collapse <<	Not Applicable	Completed	-	United States, Oregon ... more >> Oregon Health & Science University Portland, Oregon, United States, 97238 Collapse <<
NCT01956838	Obesity	Not Applicable	Completed	-	Netherlands ... more >> Maastricht University Medical Center Maastricht, Netherlands Collapse <<
NCT03693742	Prostate Cancer ... more >> Prostate Cancer Metastatic Prostatic Neoplasm Collapse <<	Not Applicable	Not yet recruiting	December 31, 2019	Canada, British Columbia ... more >> BC Cancer Not yet recruiting Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Hayley Allan 604-877-6000 ext 2818 hayley.allan@bccancer.bc.ca Principal Investigator: Francois Benard, MD Collapse <<
NCT01410838	Obesity Weigh... more >>t Gain Food Preferences Collapse <<	Not Applicable	Completed	-	United States, California ... more >> Western Human Nutrition Center, University of California Davis Davis, California, United States, 95616 Collapse <<
NCT02390180	-	-	Completed	-	United States, Indiana ... more >> Purdue University West Lafayette, Indiana, United States, 47907 Collapse <<
NCT02446106	Nutrition Intervention	Not Applicable	Completed	-	United Kingdom ... more >> Leatherhead Food Research Leatherhead, Surrey, United Kingdom, KT22 7RY Collapse <<
NCT03425578	Healthy	Not Applicable	Recruiting	December 2018	Canada, Ontario ... more >> University of Waterloo Recruiting Waterloo, Ontario, Canada, N2L 3G1 Contact: Kirsten E Bell, PhD Collapse <<
NCT02745028	Delayed Gastric Emptying	Not Applicable	Withdrawn(The protocol was can... more >>celled becouse lack of funding) Collapse <<	October 2017	-
NCT01009658	Gastroesophageal Reflux	Not Applicable	Completed	-	Japan ... more >> Gunma university hospital Maebashi, Gunma, Japan, 3718511 Collapse <<
NCT01761045	Nutrition Intervention	Not Applicable	Completed	-	United States, New Jersey ... more >> IBERICA Clinical Research Center Eatontown, New Jersey, United States, 07724 Collapse <<
NCT00862017	Healthy	Not Applicable	Completed	-	France ... more >> Centre de recherche sur volontaires Bobigny, France, 93 Collapse <<

谷氨酸单钠盐 Catalog No. CSN11296

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