|(S)-2-羟基戊二酸钠|CsnPharm

CAS No.: 63512-50-5

(S)-2-羟基戊二酸钠 Catalog No. CSN27531

Synonyms: (S)-2-Hydroxyglutaric acid disodium;L-α-Hydroxyglutaric Acid (sodium salt);L-2-HG

L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.

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描述L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzyme. 2HG can inhibit 2-oxoglutaratre (2-OG)-dependent dioxygenases that mediate epigenetic events, including DNA and histone demethylation^[3]. L-2-Hydroxyglutaric acid (LGA) is the biochemical hallmark of patients affected by the neurometabolic disorder known as L-2-hydroxyglutaric aciduria (LHGA). tCK activity was significantly inhibited by LGA in the cerebellum, but not in cerebral cortex, cardiac muscle and skeletal muscle. Furthermore, CK activity from the mitochondrial fraction was inhibited by LGA, whereas that from the cytosolic fraction of cerebellum was not affected by the acid. The inhibitory effect of LGA on tCK was fully prevented by pre-incubation of the homogenates with reduced glutathione (GSH), suggesting that this inhibition is possibly mediated by oxidation of essential thiol groups of the enzyme^[4]. L-2-HG was intracerebrally administered to rat pups at postnatal day 1 (P1) to induce a rise of L-2-HG (L-2-hydroxyglutaric acid) levels in the central nervous system (CNS). L-2-HG markedly induced the generation of reactive oxygen species (increase of 2',7'-dichloroflurescein-DCFH-oxidation), lipid peroxidation (increase of malondialdehyde concentrations), and protein oxidation (increase of carbonyl formation and decrease of sulfhydryl content), besides decreasing the antioxidant defenses (reduced glutathione-GSH) and sulfhydryl content in the cerebral cortex^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2062 mL
- 26.0311 mL
- 52.0623 mL
- 5 mM
- 1.0412 mL
- 5.2062 mL
- 10.4125 mL
- 10 mM
- 0.5206 mL
- 2.6031 mL
- 5.2062 mL

技术信息

CAS号

63512-50-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H6Na2O5

运输

蓝冰

分子量

192.08

别名

(S)-2-Hydroxyglutaric acid disodium;L-α-Hydroxyglutaric Acid (sodium salt);L-2-HG;L-2-Hydroxyglutarate;L-2-Hydroxyglutaric Acid;(S)-2-Hydroxypentanedioic Acid

溶解度

DMSO	Insoluble
Ethanol	Insoluble

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